Product Name	TGFB4/LEFTY2
Chinese Name	转化生长因子β4抗体
Alias	EBAF; Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily); Endometrial bleeding associated factor; Endometrial bleeding-associated factor; Left right determination factor 2; Left right determination factor A; Left-right determination factor 2; Left-right determination factor A; LEFTA; LEFTY 2; LEFTY2; LEFTYA; LFTY2_HUMAN; MGC46222; Protein lefty 2; Protein lefty A; Protein lefty-2; Protein lefty-A; Protein lefty2; PSEC0024; TGF beta 4; TGF-beta-4; TGFB4; Transforming growth factor beta 4; Transforming growth factor beta-4.
Research Area	Tumour  immunology  Signal transduction  Stem cells  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	32kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TGFB4: 281-366/366
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	LEFTY2 is a member of the TGF-beta family of proteins. LEFTY2 is secreted and plays a role in left-right asymmetry determination of organ systems during development and may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Function: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Subcellular Location: Secreted. Tissue Specificity: Mesenchymal cells of the endometrial stroma. Post-translational modifications: The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner. DISEASE: Defects in LEFTY2 are the cause of left-right axis malformations (LRAM) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava. Similarity: Belongs to the TGF-beta family. SWISS: O00292 Gene ID: 7044 Database links: Entrez Gene: 7044 Human Entrez Gene: 320202 Mouse Entrez Gene: 289316 Rat Omim: 601877 Human SwissProt: O00292 Human SwissProt: P57785 Mouse Unigene: 520187 Human Unigene: 87078 Mouse Unigene: 215726 Rat
Product Picture	Sample: A431(Human) Cell Lysate at 30 ug Primary: Anti-LEFTY2  (SL5778R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 32 kD

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