Product Name	Epigen
Chinese Name	epithelial cells有丝分裂蛋白抗体
Alias	EPG; Epigen precursor; Epithelial mitogen; EPGN_HUMAN.
literatures	Specific References  (2)     |     SL5767R has been referenced in 2 publications. [IF=38.637] Emma D. Wrenn. et al. Regulation of Collective Metastasis by Nanolumenal Signaling. Cell. 2020 Oct;183:395  IF ;  Human.   PubMed:33007268 [IF=4.994] Ma S et al. ErbB3 Ligand Heregulin1 Is a Major Mitogenic Factor for Uncontrolled Lung Cancer Cell Proliferation.Neoplasia. 2019 Apr;21(4):343-352.  IHC-P ;  Mouse.   PubMed:30831376
Research Area	Tumour  immunology  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	15kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Epigen: 51-130/154 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. It is produced in several tissues, including the testis, liver, heart and in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. Function: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. Subcellular Location: Isoform 1: Membrane; Single-pass type I membrane protein (Probable). Isoform 2: Membrane; Single-pass type I membrane protein (Probable). Isoform 3: Secreted (Probable). Isoform 4: Secreted (Probable). Isoform 5: Secreted (Probable). Isoform 6: Secreted (Probable). Similarity: Contains 1 EGF-like domain. SWISS: Q6UW88 Gene ID: 255324 Database links: Entrez Gene: 255324 Human Entrez Gene: 71920 Mouse SwissProt: Q6UW88 Human SwissProt: Q924X1 Mouse Unigene: 401237 Human Unigene: 197319 Mouse

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