Product Name	DCK
Chinese Name	脱氧胞苷激酶抗体
Alias	DCK; dCK; DCK protein; DCK_HUMAN; Deoxycytidine kinase; EC 2.7.1; EC 2.7.1.74; MGC117410; MGC138632; OTTHUMP00000219118; OTTHUMP00000219119.
Research Area	Tumour  Chromatin and nuclear signals  Signal transduction  Cyclin  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	31kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DCK: 181-260/260
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside. Function: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Subunit: Homodimer. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1. Similarity: Belongs to the DCK/DGK family. SWISS: P27707 Gene ID: 1633 Database links: Entrez Gene: 1633 Human Entrez Gene: 13178 Mouse Entrez Gene: 79127 Rat Omim: 125450 Human SwissProt: Q3MHR2 Cow SwissProt: P27707 Human SwissProt: P43346 Mouse SwissProt: P48769 Rat Unigene: 709 Human Unigene: 298892 Mouse Unigene: 10058 Rat

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