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Product Name CABLES2 Chinese Name Cyclin依赖性激酶CABLES2抗体 Alias CABLES 2; Cdk5 and Abl enzyme substrate 2; Ik3 2 ; Interactor with CDK3 2; C20orf150; CABL2_HUMAN. Research Area Tumour Cell biology immunology Cyclin Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 52kDa Cellular localization The nucleus cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CABLES2: 101-200/478 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail CABLES2 is a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. ik3-1/CABLES1, a closely related molecule, has been identified to be a candidate tumor suppressor for colon and head/neck cancers. The exact function of this protein is unknown, but it is probably involved in G1-S cell cycle transition. CABLES2 binds to CDK3, CDK5 and ABL1.
Function:
Unknown. Probably involved in G1-S cell cycle transition.
Subunit:
Binds to CDK3, CDK5 and ABL1. The C-terminal cyclin-box-like region binds to CDK5 (By similarity).
Similarity:
Belongs to the cyclin family.
SWISS:
Q9BTV7
Gene ID:
81928
Database links:Entrez Gene: 81928 Human
Entrez Gene: 252966 Mouse
SwissProt: Q9BTV7 Human
SwissProt: Q8K3M5 Mouse
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