TEL: +86 571 56623320 EMAIL: [email protected]
Product Name FGFR1OP Chinese Name 成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体 Alias FGFR1OP; Fibroblast growth factor receptor 1 oncogene partner; FOP; FR1OP_HUMAN. Research Area Tumour Cell biology immunology Neurobiology Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 43kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FGFR1OP: 131-230/399 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail FGFR1 Oncogene Partner is required for anchoring microtubules to the centrosomes. Ubiquitous; highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). There are three named isoforms.
Function:
Required for anchoring microtubules to the centrosomes.
Subunit:
Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1.
Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Note=Associated with gamma-tubulin.
Tissue Specificity:
Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.
DISEASE:
Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
Similarity:
Belongs to the FGFR1OP family.
Contains 1 LisH domain.
SWISS:
O95684
Gene ID:
11116
Database links:Entrez Gene: 11116 Human
Entrez Gene: 75296 Mouse
Omim: 605392 Human
SwissProt: Human
SwissProt: O95684 Human
SwissProt: Q66JX5 Mouse
Unigene: 487175 Human
Unigene: 227250 Mouse
Unigene: 166829 Rat
FGFR1OP蛋白最初是在引起Stem cells骨髓增生病的癌蛋白中作为FGFR1的融合伴侣被发现的,目前研究认为,FGFR1OP蛋白在很多组织细胞中都有不同的存在,尤其是以脑, 心,肝,肌肉,肾,小肠,结肠,肾上腺,前列腺,睾丸和胰腺中高表达。
Scan Wechat Qrcode