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Product Name ALDH1L1 Chinese Name 乙醛脱氢酶1蛋白家族L1抗体 Alias AL1L1_HUMAN; Cytosolic 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase family 1 member L1; FTHFD; EC:1.5.1.6; 10-FTHFDH; FDH; 10-fTHF; Research Area Tumour Neurobiology Signal transduction Apoptosis Cell adhesion molecule Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Pig, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 100kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ALDH1L1: 451-550/902 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Highly expressed in liver, pancreas and kidney.
SWISS:
O75891
Gene ID:
10840
Database links:Entrez Gene: 10840 Human
Entrez Gene: 107747 Mouse
SwissProt: O75891 Human
SwissProt: Q8R0Y6 Mouse
Product Picture Tissue/cell: Rat kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-ALDH1L1 Polyclonal Antibody, Unconjugated(SL5709R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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