Product Name	FXR1
Chinese Name	脆性X相关蛋白1/脆性X智力低下综合征相关蛋白1抗体
Alias	Fragile X mental retardation syndrome related protein 1; FXR1; hFXR1p; 1110050J02Rik; 9530073J07Rik; AA959924; AI851072; FXR1H; FXR1P.
Research Area	Cell biology  immunology  Chromatin and nuclear signals  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	62-74kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FXR1: 121-220/621
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in all tissues examined including heart, brain, kidney and testis. Similarity: Expressed in all tissues examined including heart, brain, kidney and testis. Belongs to the FMR1 family. Contains 2 Agenet-like domains. Contains 2 KH domains. SWISS: P51114 Gene ID: 8087 Database links: Entrez Gene: 8087 Human Entrez Gene: 14359 Mouse Entrez Gene: 361927 Rat Omim: 600819 Human SwissProt: P51114 Human SwissProt: Q61584 Mouse SwissProt: Q5XI81 Rat Unigene: 478407 Human Unigene: 259021 Mouse Unigene: 40468 Rat 脆性X综合症，又称马丁－贝尔综合症，是一种遗传疾病。该综合症可以导致一系列的特征性症状，包括生理、智力、情绪、以及行为上的异常。症状的轻重各有不同。该疾病伴随着X染色体上一个简单的三核苷酸基因序列（CGG）的扩增。这种扩增导致了一种称为FMR-1的蛋白质无法在病人体内表达，而该蛋白质是神经的正常发育必不可少的。 根据CGG重复序列的长度，目前普遍认可将脆性X综合症分为四种类型：正常人（含有19－31个CGG重复序列），前突变者（含有55－200个CGG重复序列），全突变者（含有200个以上的CGG重复序列），过渡型，又称“灰色区域型”（含有40－60个重复）。脆性X综合征这是一种导致智力低下的遗传疾病，是导致人群中智力低下的第二大病因——仅次于21三体综合症。
Product Picture	Sample: Heart (Mouse) Lysate at 40 ug Brain (Mouse) Lysate at 40 ug Primary: Anti-FXR1 (SL5528R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 62-74 kD Observed band size: 60 kD

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