Product Name	phospho-JunB (Ser259)
Chinese Name	磷酸化活化蛋白激酶B抗体
Alias	JunB (phospho S259); JunB (phospho S259); p-JunB (phospho S259); JunB (phospho-Ser259); JUNB_HUMAN; Transcription factor JunB; Transcription factor jun B; Transcription factor AP-1 subunit JunB; Jun B;
Product Type	Phosphorylated anti
Research Area	Tumour  transcriptional regulatory factor  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	38kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human JunB around the phosphorylation site of Ser259: PV(p-S)PI
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The cJun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus vjun oncogene. JunB and JunD have been shown to be almost identical to cJun in their C terminal regions, which are involved in dimerization and DNA binding, whereas their N terminal domains, which are involved in transcriptional activation, diverge. JunB is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'. Function: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. Subunit: Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains). Subcellular Location: Nucleus. Post-translational modifications: Ubiquitinated by ITCH, leading to its degradation. Similarity: Belongs to the bZIP family. Jun subfamily. Contains 1 bZIP (basic-leucine zipper) domain. SWISS: P17275 Gene ID: 3726 Database links: Entrez Gene: 3726 Human Entrez Gene: 16477 Mouse Entrez Gene: 24517 Rat SwissProt: P17275 Human SwissProt: P09450 Mouse SwissProt: P24898 Rat

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