Product Name	Cystatin B
Chinese Name	胱抑素B/半胱氨酸蛋白酶抑制剂B抗体
Alias	CPI B; CPI-B; CST6; CSTB; Cystatin B; Cystatin-B; CYTB; EPM1; Liver thiol proteinase inhibitor; PME; STFB; CHROW21; CYTB_HUMAN; EPM1A; Stefin-B; ULD.
Research Area	Tumour  Cell biology  immunology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	14kDa
Cellular localization	The nucleus cytoplasmic Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Cystatin B: 51-98/98
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq, Jul 2008] Function: Shows moderate inhibition of cathepsin B but is not active against cathepsin C. Subcellular Location: Cytoplasm. Nucleus.Secreted. Tissue Specificity: Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity. Post-translational modifications: Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor. Similarity: Belongs to the cystatin family. SWISS: P04080 Gene ID: 1476 Database links: Entrez Gene: 1476 Human Entrez Gene: 13014 Mouse Entrez Gene: 25308 Rat Omim: 601145 Human SwissProt: P04080 Human SwissProt: Q76LA1 Human SwissProt: Q62426 Mouse SwissProt: P01041 Rat Unigene: 695 Human Unigene: 6095 Mouse Unigene: 1233 Rat

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