Product Name	CXCL12
Chinese Name	基质细胞衍生因子1抗体
Alias	SDF1 alpha; C-X-C motif chemokine 12; Chemokine (C X C motif) ligand 12; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF; PBSF; Pre B cell growth stimulating factor; Pre-B cell growth-stimulating factor; SCYB12; SDF 1 alpha; SDF-1; SDF 1 beta; SDF 1b; SDF-1; SDF-1-alpha(3-67); SDF1; SDF1_HUMAN; SDF1a; SDF1b; Stromal cell derived factor 1; TLSF a; TLSF b; TLSFa; TLSFb; TPAR1.
literatures	Specific References  (9)     |     SL4938R has been referenced in 9 publications. [IF=11.75] Grootaert, Mandy OJ, et al. "Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis." Autophagy (2015).  WB ;  Mouse.   PubMed:26391655 [IF=9.071] Chun-Yi Ng. et al. Endothelial-immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease. EMBO REP. 2022 Jun;23(6):e54271  IHC ;  Human.   PubMed:35403791 [IF=8.98] Pei, Guangchang, et al. "Renal Interstitial Infiltration and Tertiary Lymphoid Organ Neogenesis in IgA Nephropathy." Clinical Journal of the American Society of Nephrology (2013): CJN-01150113.  IHC-P ;  Human.   PubMed:24262509 [IF=3.636] Kawamura Teruhiko. et al. Identification of genes associated with endometrial cell ageing. Mol Hum Reprod. 2021 Feb;27(2):  IHC ;  Human.   PubMed:33258951 [IF=3.404] Yan-Cong Wang. et al. NRSF deficiency leads to abnormal postnatal development of dentate gyrus and impairment of progenitors in subgranular zone of hippocampus. 2021 May 07  IHC ;  Mouse.   PubMed:33960056 [IF=2.65] Narubhorn Ongprakobkul. et al. Effects of local vs systemic administration of CXCR4 inhibitor AMD3100 on orthodontic tooth movement in rats. Am J Orthod Dentofac. 2022 Mar;:  IHC ;  Rat.   PubMed:35248418 [IF=2.495] Qi D et al. Stromal cell‐derived factor‐1 regulates the secretion of interleukin‐1β in the temporomandibular joint of rats with synovial inflammation. J Oral Pathol Med. 2020 Oct;49(9):933-939.  IHC-P ;  Rat.   PubMed:32449535 [IF=1.591] Jikai Wang. et al. MFGE8 mitigates brain injury in a rat model of SAH by maintaining vascular endothelial integrity via TIGβ5/PI3K/CXCL12 signaling. 2021 May 15  WB ;  Rat.   PubMed:33991211 [IF=1.43] Wang, Xiao-yan, et al. "AMD3100 attenuates MMP-3 and MMP-9 expressions and prevents cartilage degradation in a monosodium iodoacetate-induced rat model of temporomandibular osteoarthritis." Journal of Oral and Maxillofacial Surgery (2016).  IHC-P ;  Rat.   PubMed:26851314
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	8kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SDF-1/CXCL12: 24-70/93
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]. Function: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and CXCR7, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of CXCR7 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Subunit: Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N-terminus of CXCR7. Subcellular Location: Secreted. Tissue Specificity: Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen. Post-translational modifications: Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans. Similarity: Belongs to the intercrine alpha (chemokine CxC) family. SWISS: P48061 Gene ID: 6387 Database links: Entrez Gene: 6387 Human Entrez Gene: 20315 Mouse Entrez Gene: 24772 Rat SwissProt: P48061 Human SwissProt: P40224 Mouse Omim: 600835 Human
Product Picture	Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Human HT-1080 tissue lysates Lane3: Human A549 cell lysates Lane4: Human HeLa cell lysates Lane 5: Human MCF-7 cell lysates Lane 6: Human HepG2 cell lysates Primary: Anti- CXCL12 (SL4938R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 8 kDa Observed band size: 10 kDa

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