Product Name	SLC40A1
Chinese Name	The cell membrane铁TransporterFP1抗体
Alias	Ferroportin 1; Ferroportin-1; FPN1; HFE4; IREG1; Iron regulated transporter 1; Iron-regulated transporter 1; MTP1; S40A1_HUMAN; SLC40A1; Solute carrier family 40 member 1; MST079; MSTP079; MTP1; SLC11A3.
literatures	Specific References  (12)     |     SL4906R has been referenced in 12 publications. [IF=7.31] Huang Bin. et al. Dapagliflozin Ameliorates Renal Tubular Ferroptosis in Diabetes via SLC40A1 Stabilization. OXID MED CELL LONGEV. 2022;2022:9735555  WB, IP ;  Mouse, Human.   PubMed:35993021 [IF=5.778]   WB ;  Rat.   PubMed:33017703 [IF=5.778] Zixuan Liu. et al. Tetrachlorobenzoquinone exposure triggers ferroptosis contributing to its neurotoxicity. Chemosphere. 2021 Feb;264:128413  WB ;  Rat.   PubMed:33017703 [IF=5.008] Rychtarcikova, Zuzana, et al. "Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism." Oncotarget (2016).  WB ;  Human.   PubMed:28031527 [IF=4.069] Gan Z et al. Regulation of macrophage iron homeostasis is associated with the localization of bacteria. Metallomics. 2019 Feb 20;11(2):454-461.  WB ;  Pig.   PubMed:30617365 [IF=3.68] Calatrava-Ferreras et al. Liver Growth Factor (LGF) Upregulates Frataxin Protein Expression and Reduces Oxidative Stress in Friedreich's Ataxia Transgenic Mice. (2016) Int.J.Mol.Sci. 17  WB ;  Mouse.   PubMed:27941692 [IF=3.546] Wang,et al.Vasoactive intestinal peptide inhibits airway smooth muscle cell proliferation in a mouse model of asthma via the ERK1/2 signaling pathway.(2018) Experimental Cell Research. 364:168-174.  WB ;  Mouse.   PubMed:29408536 [IF=3.347]   WB ;  Rat.   PubMed:32937103 [IF=3.347] Zixuan Liu. et al. Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis. Toxicol Appl Pharm. 2020 Nov;407:115241  WB ;  Rat.   PubMed:32937103 [IF=3] Ma, Sai. et al. Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction. N-S ARCH PHARMACOL. 2022 Apr;:1-18  WB ;  Rat.   PubMed:35476142 [IF=2.759] Qingxin Song. et al. Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells. Yonsei Med J. 2021 Sep 1; 62(9): 843–849  WB ;  Human.   PubMed:34427071 [IF=2.1] Zhang, L. Y., et al. "Effect of iron source on iron absorption and gene expression of iron transporters in the ligated duodenal loops of broilers." Journal of Animal Science (2017).  WB ;  Chicken.   PubMed:28464091
Research Area	Tumour  immunology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	63kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SLC40A1/FPN1: 331-430/571
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SLC40A1 may be involved in iron export from duodenal epithelial cells and also in transfer of iron between maternal and fetal circulation. It mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4, an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin. Function: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Subunit: Belongs to the S1LC40A transporter family. Subcellular Location: Cell membrane. Localized to the basolateral membrane of polarized epithelial cells. Tissue Specificity: Expressed in placenta, intestine, muscle and spleen. DISEASE: Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Similarity: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. SWISS: Q9NP59 Gene ID: 30061 Database links: Entrez Gene: 30061 Human Entrez Gene: 53945 Mouse Entrez Gene: 170840 Rat Omim: 604653 Human SwissProt: Q9NP59 Human SwissProt: Q9JHI9 Mouse SwissProt: Q923U9 Rat Unigene: 643005 Human Unigene: 28756 Mouse Unigene: 15324 Rat
Product Picture	Sample: Lane 1: Human Hepg2 cell lysates Lane 2: Human K562 cell lysates Lane 3: Human Molt-4 cell lysates Lane 4: Human Jurkat cell lysates Primary: Anti-SLC40A1 (SL4906R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 63 kDa Observed band size: 60 kDa Sample: A673(Human) Cell Lysate at 30 ug Primary: Anti-SLC40A1 (SL4906R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 63 kD Observed band size: 65 kD Sample: K562 (Human) Cell Lysate at 30 ug HepG2 (Human) Cell Lysate at 30 ug Primary: Anti-SLC40A1 (SL4906R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 63 kD Observed band size: 63 kD

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