Product Name	TREM1
Chinese Name	髓系细胞触发受体1抗体
Alias	Triggering receptor expressed on myeloid cells 1; TREM 1; TREM-1; Triggering receptor expressed on monocytes 1; Triggering receptor TREM 1; Triggering receptor TREM1; Triggering-receptor TREM 1; Triggering-receptor TREM-1; Triggering-receptor TREM1; TREM1_HUMAN; CD354.
literatures	Specific References  (8)     |     SL4886R has been referenced in 8 publications. [IF=38.079] Liu, Xuanyu. et al. Single-cell RNA sequencing of subcutaneous adipose tissues identifies therapeutic targets for cancer-associated lymphedema. CELL DISCOV. 2022 Jun;8(1):1-20  IF ;  Mouse.   PubMed:35725971 [IF=10.849] Liu, Xuanyu. et al. Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection. Cell Discov. 2022 Feb;8(1):1-21  IF ;  Mouse.   PubMed:35132073 [IF=8.484] Amir Boufenzer. et al. Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis. Cell Mol Immunol. 2021 Jan;18(2):452-460  WB ;  Human.   PubMed:33420354 [IF=3.754] Zhao,et al.Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats.(2018) Molecular and Cellular Endocrinology. :.  WB + IF(ICC) ;  Mouse.   PubMed:29331667 [IF=3.221] Chunchun Tang. et al. The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders. J NEUROIMMUNOL. 2023 Mar;:578070  WB ;  Mouse.   PubMed:10.1016/j.jneuroim.2023.578070 [IF=2.523] Zhi Chen. et al. Klotho deficiency aggravates diabetes-induced podocyte injury due to DNA damage caused by mitochondrial dysfunction. Int J Med Sci. 2020; 17(17): 2763–2772  WB ;  Mouse.   PubMed:33162804 [IF=1.347] Teng,et al.Anti-inflammatory effect of tranexamic acid against trauma-hemorrhagic shock-induced acute lung injury in rats.(2018) Experimental Animals. :.  WB ;  Rat.   PubMed:29398669 [IF=1.203] Nurettin Aydoğdu et al. The Effects of Irisin on Nω-Nitro-L-arginine Methyl Ester Hydrochloride-Induced Hypertension in Rats. Balkan Med J 2019;36:337-46.  IHC-P ;  Rat.   PubMed:DOI:10.4274/balkanmedj.galenos.2019.2019.5.113
Research Area	Cell biology  immunology  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/Test IF=1:100-500  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse TREM1: 65-150/230 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]. Function: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). Subunit: Contains 1 Ig-like V-type (immunoglobulin-like) domain. Subcellular Location: Secreted and Cell membrane. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: Q9JKE2 Gene ID: 58217 Database links: Entrez Gene: 54210 Human Entrez Gene: 58217 Mouse Entrez Gene: 301229 Rat Omim: 605085 Human SwissProt: Q9NP99 Human SwissProt: Q9JKE2 Mouse Unigene: 283022 Human Unigene: 248352 Mouse
Product Picture	Sample: Liver (Rat) Lysate at 40 ug Primary: Anti-TREM1 (SL4886R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 23 kD Observed band size: 25 kD Sample: kidney (Mouse) Lysate at 40 ug Primary: Anti-TREM1 (SL4886R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 23 kD Observed band size: 25 kD Blank control (black line): Mouse spleen(Black). Primary Antibody (green line): Rabbit Anti-TREM1 antibody (SL4886R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE Dilution: 1μg /test. Protocol The cells were fixed with 4% paraformaldehyde for 10 min at room temperature. The cells were then incubated in 5% BSA to block non-specific protein-protein interactions for 30 min at room temperature. Cells stained with Primary Antibody for 30 min at room temperature The secondary antibody used for 40 min at room temperature. Acquisition of 10,000 events was performed.

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