Product Name	Bone Sialoprotein
Chinese Name	骨涎蛋白
Alias	BNSP; Bone sialoprotein II; BSP; BSPII; Cell binding sialoprotein; Integrin binding sialoprotein; SPII; SIAL_HUMAN; Bone sialoprotein 2; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein.
literatures	Specific References  (2)     |     SL4729R has been referenced in 2 publications. [IF=2.81] Han et al. β-catenin enhances odontoblastic differentiation of dental pulp cells through activation of Runx2. (2014) PLoS.On. 9:e88890  WB ;  Human.   PubMed:24520423 [IF=1.26] Bugueño, Juan, et al. "Canine mesenchymal stem cell bone regenerative capacity is regulated by site-specific multi-lineage differentiation." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (2016).  WB ;  Dog.   PubMed:27876576
Research Area	Cell biology  Stem cells  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Horse, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	35kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse Bone Sialoprotein: 241-317/317
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008] Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. Subcellular Location: Secreted. Post-translational modifications: N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains. Sulfated on either Tyr-320 or Tyr-321 (By similarity). SWISS: Q61711 Gene ID: 15891 Database links: Entrez Gene: 3381 Human Entrez Gene: 15891 Mouse Entrez Gene: 24477 Rat Omim: 147563 Human SwissProt: P21815 Human SwissProt: Q61711 Mouse SwissProt: P13839 Rat Unigene: 518726 Human Unigene: 4987 Mouse Unigene: 9721 Rat

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