Product Name	MRC1
Chinese Name	巨噬细胞甘露糖受体 (CD206) 抗体
Alias	Mannose Receptor; C-type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor; Mannose receptor C type 1; MMR; MRC 1; MRC-1; MRC1_HUMAN; Macrophage mannose receptor 1; MRC1L1; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1.
literatures	Specific References  (31)     |     SL4727R has been referenced in 31 publications. [IF=20.722] Meng Lin. et al. CRISPR-based in situ engineering tumor cells to reprogram macrophages for effective cancer immunotherapy. Nano Today. 2022 Feb;42:101359  IF ;  Mouse.   PubMed:10.1016/j.nantod.2021.101359 [IF=15.304] Xuan Li. et al. ROS-responsive hydrogel coating modified titanium promotes vascularization and osteointegration of bone defects by orchestrating immunomodulation. BIOMATERIALS. 2022 Aug;287:121683  IHC ;  Rat.   PubMed:35870263 [IF=11.05] Locatelli, Luigi, et al. "Macrophage recruitment by fibrocystin‐defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis."Hepatology (2016).  IHC-P ;  Mouse.   PubMed:26645994 [IF=8.579] Tong L et al. ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma. Theranostics. 2020 May 1;10(13):5943-5956.  IHC ;  Mouse.   PubMed:32483429 [IF=8.56] Das, Anusuya, et al. "Bioactive lipid coating of bone allografts directs engraftment and fate determination of bone marrow-derived cells in rat GFP chimeras." Biomaterials (2015).  IHC-P ;  Mouse.   PubMed:26125501 [IF=8.352] Ye Hea et al. Improved osteointegration by SEW2871-encapsulated multilayers on micro-structured titanium via macrophages recruitment and immunomodulation. Applied Materials Today 20 (2020) 100673  IHC/IF ;  Rat/Mouse.   PubMed:10.1016/j.apmt.2020.100673 [IF=7.367] Yitian Du. et al. Engineered Microglia Potentiate the Action of Drugs against Glioma Through Extracellular Vesicles and Tunneling Nanotubes. 2021 Feb 28  IF,IHC ;  Mouse.   PubMed:33644993 [IF=7.035] Xin Li. et al. Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway. CNS NEUROSCI THER. 2023 Apr;:  FC ;  Mouse.   PubMed:37032648 [IF=6.092]   IF ;  mouse.   PubMed:32786521 [IF=6.092] Sha Liu. et al. Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing. Biomacromolecules. 2020;21(9):3795–3806  IF ;  Mouse.   PubMed:32786521 [IF=5.714] Liu J et al. Polychlorinated biphenyl quinone promotes macrophage polarization to CD163+ cells through Nrf2 signaling pathway. Environmental Pollution,2019, 113587.  WB ;  Mouse.   PubMed:doi:10.1016/j.envpol.2019.113587 [IF=5.57] Ma R et al. Exploring the interactions between engineered nanomaterials and immune cells at 3D Nano-bio interfaces to discover potent Nano-adjuvants. Nanomedicine. 2019 Jun 18;21:102037.  Other ;  Human.   PubMed:31220596 [IF=5.48] Karmouty-Quintana, Harry, et al. "Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension." The FASEB Journal (2014): fj-14.  IHC-P ;  Mouse.   PubMed:25318478 [IF=5.36] Azad, Abul K., et al. "γ-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206)." The Journal of Immunology (2015): 1402005.  other ;  Human.   PubMed:26202986 [IF=5.267] White,et al.GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.(2018) Endocrine-Related Cancer. 25:453-469.  WB ;  Human.   PubMed:29431615 [IF=5.047] Xie W et al. Dose Dependent Modulation of Bioactive Glasses Particles on Macrophage and Diabetic Wound Healing. Journal of Materials Chemistry B. 2018.  IHC ;  Rat.   PubMed:doi:10.1039/c8tb02938e [IF=4.854] Linghao Xiao. et al. Osteogenic capacity of octacalcium phosphate involving macrophage polarization. J BIOMED MATER RES A. 2022 Dec;:  IHC ;  Rat.   PubMed:36573692 [IF=4.784] Zhan Q et al. Structural Characterization and Immunomodulatory Activity of a Novel Acid Polysaccharide Isolated from the Pulp of Rosa laevigata Michx Fruit. Int J Biol Macromol. 2019 Nov 12. pii: S0141-8130(19)37108-9.  Other ;  Mouse.   PubMed:31730989 [IF=4.708] Jiang L et al. Sonodynamic Therapy in Atherosclerosis by Curcumin Nanosuspensions: Preparation design, Efficacy Evaluation, and Mechanisms Analysis. Eur J Pharm Biopharm. 2020 Jan;146:101-110.  IHC-P ;  Mouse.   PubMed:31841689 [IF=4.344] Gitto SB et al. Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells. Cell Commun Signal. 2020 Jun 17;18(1):95.  IHC-P ;  Mouse.   PubMed:32552827 [IF=4.323] Nishikawa,et al.Highly Dispersible and Bioavailable Curcumin but not Native Curcumin Induces Brown-Like Adipocyte Formation in Mice.(2018) Molecular Nutrition & Food Research. 62:.  IF(IHC-P) ;  Mouse.   PubMed:29334590 [IF=4.291] Nguyen, Thao K. T.. et al. Recombinant Human Lactoferrin Reduces Inflammation and Increases Fluoroquinolone Penetration to Primary Granulomas During Mycobacterial Infection of C57Bl/6 Mice. Arch Immunol Ther Ex. 2022 Dec;70(1):1-13  IHC ;  Mouse.   PubMed:35226195 [IF=4.12] Nakai et al. IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice. (2017) Sci.Rep. 7:12473  IHC,WB ;  Mouse.   PubMed:28963556 [IF=3.687] Masuda J et al. Cytokine expression and macrophage localization in xenograft and allograft tumor models stimulated with lipopolysaccharide.Int J Mol Sci. 2018 Apr 23;19(4).  IHC ;  Mouse.   PubMed:29690614 [IF=3.448] Žaloudíková M et al. The effect of exposure to hypoxia on superoxide formation by alveolar macrophages is indirect. Life Sci. 2019 Sep 10;236:116864.  ICC ;  Rat.   PubMed:31518607 [IF=2.895] Shao N et al. A Multi‐Functional Silicon Nanoparticle Designed for Enhanced Osteoblast Calcification and Related Combination Therapy. Macromol Biosci. 2019 Nov 10:e1900255.  FCM&ICF ;  Mouse.   PubMed:31709759 [IF=2.876] Shi F et al. Heat injured stromal cells-derived exosomal EGFR enhances prostatic wound healing afterthulium laser resection through EMT and NF-κB signaling. Prostate. 2019 May 24.  IHF ;  Dog.   PubMed:31124594 [IF=2.47] Struecker, B., et al. "Implantation of a Tissue-Engineered Neo-Bile Duct in Domestic Pigs." European Surgical Research 56.1-2 (2015): 61-75.  IHC-P ;   PubMed:26684913 [IF=2.38] Ding, Peng, et al. "Expression of Tumor-Associated Macrophage in Progression of Human Glioma." Cell Biochemistry and Biophysics (2014): 1-7.  IHC-P ;  Human.   PubMed:25182001 [IF=1.713] Hao Liu. et al. A 14 bp indel polymorphism in the promoter region is associated with different responses to porcine circovirus type 2 infection by regulating MRC1 transcription. Vet Immunol Immunop. 2021 Apr;234:110202  WB ;  Pig.   PubMed:33578325
Research Area	Cell biology  immunology  transcriptional regulatory factor  The cell membrane受体  glycoprotein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=2μg /Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	160kDa
Detection molecular weight	180-200 kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MRC1/CD206: 201-300/1456 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region. [provided by RefSeq] Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. Subcellular Location: Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Similarity: Contains 8 C-type lectin domains. Contains 1 fibronectin type-II domain. [SIMILARITY] Contains 1 ricin B-type lectin domain. SWISS: P22897 Gene ID: 4360 Database links: Entrez Gene: 4360 Human Entrez Gene: 17533 Mouse Entrez Gene: 291327 Rat Omim: 153618 Human SwissProt: P22897 Human SwissProt: Q61830 Mouse Unigene: 75182 Human Unigene: 2019 Mouse 巨噬细胞甘露糖受体,主要存在于巨噬The cell membrane表面的模式识别受体，能够特异性识别甘露糖、岩藻糖或N-乙酰葡糖胺，介导巨噬细胞吞噬抗原，启动免疫反应.
Product Picture	Blank control (blue line): Hep G2(fixed with 70% ethanol Overnight at 4℃). Primary Antibody (green line): Rabbit Anti-Macrophage mannose receptor 1 antibody (SL4727R),Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE,Dilution: 1μg /test. Blank control: THP-1. Primary Antibody (green line): Rabbit Anti-Macrophage mannose receptor 1 antibody (SL4727R) Dilution: 2μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-FITC Dilution: 0.5μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 0.1% PBST for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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