Product Name	Klrb1c
Chinese Name	NKR-P1C（NK1.1）抗体
Alias	Killer cell lectin-like receptor subfamily B member 1C; Killer cell lectin-like receptor subfamily B member 1; CD161 antigen-like family member C; Lymphocyte antigen 55c; Ly-55c; NK1.1; NKR-P1.9; NKR-P1C; Natural killer cell surface protein P1-40; NKR-P1 40; CD161c; Ly55c; Nkrp1c; KLRBC_MOUSE;
literatures	Specific References  (7)     |     SL4682R has been referenced in 7 publications. [IF=17.694] Kim, Hyun-Jin. et al. Blood monocyte-derived CD169+ macrophages contribute to antitumor immunity against glioblastoma. NAT COMMUN. 2022 Oct;13(1):1-14  IHC ;  Mouse.   PubMed:36266311 [IF=7.56] Cheekatla, Satyanarayana Swamy, et al. "NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection." PLoS Pathog 12.10 (2016): e1005972.  IHC-P ;  Mouse.   PubMed:27783671 [IF=6.107] Leimbacher Aurelia C.. et al. Voluntary Exercise Does Not Always Suppress Lung Cancer Progression. ISCIENCE. 2023 Jan 31  IHC ;  Mouse.   PubMed:10.2139/ssrn.4339786 [IF=3.478] Liu G et al. B-cell leukemia/lymphoma 11 promotes angiogenesis in an experimental corneal neovascularization model. Eye,2018 32(7), 1220–1232.  IF ;  Mouse.   PubMed:10.1038/s41433-018-0040-x [IF=2.388] Ina Bähr. et al. Characterization of natural killer cells in colorectal tumor tissue of rats fed a control diet or a high-fat diet. Ann Anat. 2021 Jan;233:151586  IHC ;  Rat.   PubMed:32916268 [IF=2.28] Liu et al. B-cell leukemia/lymphoma 10 promotes angiogenesis in an experimental corneal neovascularization model. (2018) Eye.(Lond).  IF(ICC) ;  Mouse.   PubMed:29515217 [IF=0] Uchida T et al. Activated natural killer T cells in mice induce acute kidney injury with hematuria through possibly common mechanisms shared by human CD56+ T cells.Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F618-F627.  IHF-P ;  Mouse.   PubMed:29993279
Research Area	immunology  Stem cells  Cell type markers  Natural killer cells  lymphocyte  t-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Detection molecular weight	40-48 kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse CD161c/NK1.1: 101-200/223 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Enables identical protein binding activity and signaling receptor activity. Acts upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in thymus primordium. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Nov 2021] Function: Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production. Subunit: Homodimer; disulfide-linked. Interacts with tyrosine kinase LCK. Subcellular Location: Membrane; Single-pass type II membrane protein. Tissue Specificity: Expressed in natural killer cells. SWISS: P27814 Gene ID: 17059 Database links: Entrez Gene: 17059 Mouse Entrez Gene: 362443 Rat SwissProt: P27814 Mouse SwissProt: Q0ZUP0 Rat
Product Picture	Sample: Lane 1: Human U937 cell Lysates Lane 2: Human Jurkat cell Lysates Lane 3: Human MOLT4 cell Lysates Lane 4: Human MCF-7 cell Lysates Primary: Anti-CD161c (SL4682R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25kDa Observed band size: 45kDa Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Mouse Thymus tissue lysates Lane 3: Mouse Lung tissue lysates Lane 4: Mouse Liver tissue lysates Lane 5: Rat Thymus tissue lysates Lane 6: Rat Liver tissue lysates Primary: Anti-Klrb1 (SL4682R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25 kDa Observed band size: 48 kDa

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