Product Name	PTPLA
Chinese Name	蛋白酪氨酸磷酸酶PTPLA抗体
Alias	3-hydroxyacyl-CoA dehydratase 1; CAP; Cementum attachment protein; HACD1; HACD1_HUMAN; Protein-tyrosine phosphatase-like member A; PTPLA; RP23-334M9.1.
Research Area	Tumour  Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	32kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PTPLA: 1-100/288 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008] Function: Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. Similarity: Belongs to the very long-chain fatty acids dehydratase HACD family. SWISS: B0YJ81 Gene ID: 9200 Database links: Entrez Gene: 9200 Human Entrez Gene: 30963 Mouse Omim: 610467 Human SwissProt: B0YJ81 Human SwissProt: Q9QY80 Mouse Unigene: 114062 Human

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