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Product Name MMP3 Chinese Name 基质金属蛋白酶3抗体 Alias MMP3_HUMAN; Stromelysin-1; EC:3.4.24.17; STMY1; SL-1; SL 1; SL1; Matrix metalloproteinase-3 (MMP-3); MMP-3; MMP 3; Transin-1; Research Area Tumour Immunogen Species Rabbit Clonality Polyclonal React Species Human, Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 52kDa Cellular localization Extracellular matrix Secretory protein Form Liquid Concentration 1mg/ml immunogen Recombinant human MMP-3 protein: 18-477/477 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008].
Function:
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Subcellular Location:
Secreted, extracellular space, extracellular matrix (Probable).
Similarity:
Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains.
SWISS:
P08254
Gene ID:
4314
Database links:Entrez Gene: 4314 Human
Entrez Gene: 17392 Mouse
Omim: 185250 Human
SwissProt: P08254 Human
SwissProt: P28862 Mouse
Unigene: 375129 Human
Synthesis and Degradation(Synthesis and Degradation) 基质金属蛋白酶(matrix metalloproteinases, MMPs)是一族依赖锌离子而降解各种Extracellular matrix的蛋白酶,亦称IV型胶原酶或称明胶酶A,其主要功能为降解IV型胶原,因而它在Tumour细胞突破基底膜屏障和浸润转移中起重要作用。 MMP3目前主要用于各种恶性Tumour(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)中的基底膜检测与Tumour转移浸润的研究。Product Picture Sample:
Lane 1: Human MMP-3 Protein at 50ng
Lane 2: Human MMP-3 Protein at 500ng
Primary: Rabbit Anti-MMP-3 Protein Antibody at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 60kD
Observed band size: kD
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