Product Name	FAT
Chinese Name	钙粘蛋白家族成员7抗体
Alias	Cadherin family member 7; cadherin family member 7 precursor; cadherin ME5; Cadherin related tumor suppressor; Cadherin related tumor suppressor homolog; cadherin related tumor suppressor homolog precursor; Cadherin related tumor suppressor homolog precursor (FAT protein homolog); CDHF 7; CDHF7; FAT 1; FAT tumor suppressor 1; FAT tumor suppressor homolog 1; FAT1; hFat 1; hFAT; hFat1; homolog of Drosophila FAT protein; homolog of Drosophila FAT protein precursor; homolog of Drosophila tumor suppressor FAT precursor; ME 5; ME5; Protein fat homolog.
Research Area	Tumour  Cell biology  immunology  Cyclin  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	506kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FAT/CDHF7: 1401-1500/4588
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq]. Function: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. Subunit: Interacts (via the C-terminus 4300-4400 AA) with ATN1. Interacts with RERE. Interacts (via EVH1 domains) with ENAH. Interacts (via cytoplasmic domain) with CTNNB1. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Nucleus Cytoplasm, perinuclear region. Tissue Specificity: Expressed in many epithelial and some endothelial and smooth muscle cells. Post-translational modifications: Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus. SWISS: Q14517 Gene ID: 2195 Database links: Entrez Gene: 2195 Human Entrez Gene: 14107 Mouse Omim: 600976 Human SwissProt: Q14517 Human Unigene: 481371 Human Unigene: 27365 Mouse
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat liver tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FAT) Polyclonal Antibody, Unconjugated (SL4278R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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