Product Name	DBC2
Chinese Name	乳腺癌基因删除蛋白2抗体
Alias	DBC 2; Deleted in breast cancer 2; Deleted in breast cancer 2 gene protein; E130206H14Rik; KIAA0717; p83; RBT2; RHBT2_HUMAN; Rho related BTB domain containing 2; Rho related BTB domain containing protein 2; Rho-related BTB domain containing 2; Rho-related BTB domain-containing protein 2; RHOBTB 2; Rhobtb2.
literatures	Specific References  (1)     |     SL4274R has been referenced in 1 publications. [IF=7.032] Hyun Jeong Seok. et al. Novel miR-5088-5p promotes malignancy of breast cancer by inhibiting DBC2. Mol Ther-Nucl Acids. 2021 May;:  IHC ;  Mouse, Human.   PubMed:10.1016/j.omtn.2021.05.004
Research Area	Tumour  Cell biology  immunology  Signal transduction  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	83kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DBC2: 631-727/727
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	DBC2 is a member of the recently identified RhoBTB family, which is part of the Rho GTPase family. DBC2 has been implicated as a tumor suppressor in breast and lung cancer. Studies have shown that DBC2 binds to the ubiquitin ligase scaffold Cul3, and that Cul3 regulates DBC2 protein levels by ubiquitinating DBC2 directly, leading to its degradation by the proteasome. Tissue Specificity: Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain. Similarity: Belongs to the small GTPase superfamily. Rho family. Contains 2 BTB (POZ) domains. SWISS: Q9BYZ6 Gene ID: 23221 Database links: Entrez Gene: 23221 Human Entrez Gene: 246710 Mouse Omim: 607352 Human SwissProt: Q9BYZ6 Human SwissProt: Q91V93 Mouse Unigene: 372688 Human Unigene: 102367 Mouse
Product Picture	Tissue/cell: human breast carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-DBC2 Polyclonal Antibody, Unconjugated(SL4274R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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