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Product Name CDKN2AIP Chinese Name 钙反应因子抗体 Alias Calcium response factor; CARF; CDKN2A interacting protein; CDKN2AIP; ALS2CR8; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; Calcium-response factor; CaRF; Testis development protein NYD-SP24; AL2S8_HUMAN. Research Area Tumour Cell biology immunology Chromatin and nuclear signals Cyclin Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 80kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CARF: 301-400/725 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail CARF was first cloned as a novel binding partner of ARF from a yeast interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. The p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
Function:
May be a transcription factor.
Subcellular Location:
Nucleus (Potential).
SWISS:
Q8TBM5
Gene ID:
55602
Database links:Entrez Gene: 461623 Chimpanzee
Entrez Gene: 55602 Human
Entrez Gene: 70925 Mouse
SwissProt: Q8TBM5 Human
SwissProt: Q9NXV6 Human
SwissProt: Q8BI72 Mouse
SwissProt: Q8VHI4 Mouse
Unigene: 644077 Human
Unigene: 393807 Mouse
Unigene: 16007 Rat
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