Product Name	LONP1
Chinese Name	Mitochondrion离子肽酶1抗体
Alias	Serine protease 15; hLON ATP dependent protease; Lon protease like protein; LonHS; LONP; PIM1; PRSS15; hLON; LON; lon peptidase 1, mitochondrial; LON protease; Mitochondrial ATP dependent protease Lon; Mitochondrial Ion peptidase 1; Protease serine 15.
literatures	Specific References  (4)     |     SL4245R has been referenced in 4 publications. [IF=9.207] Muñoz Vitor Rosetto. et al. Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4+/− mice. CELL MOL LIFE SCI. 2023 May;80(5):1-16  WB ;  Mouse.   PubMed:37052684 [IF=8.44] Zai, Zhuoyan. et al. Estrogen antagonizes ASIC1a-induced chondrocyte mitochondrial stress in rheumatoid arthritis. J TRANSL MED. 2022 Dec;20(1):1-14  IF ;  Rat.   PubMed:36463203 [IF=3.998] Renata R. Braga. et al. Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR mt in the hypothalamus of mice. Sci Rep-Uk. 2021 Feb;11(1):1-13  WB ;  Mouse.   PubMed:33589652 [IF=2.766] Nie et al. Down-regulating overexpressed human Lon in cervical cancer suppresses cell proliferation and bioenergetics. (2013) PLoS.One. 8:e81084  IHC ;  Human.   PubMed:24260536
Research Area	Tumour  immunology  Chromatin and nuclear signals
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	98kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LONP1: 361-460/959
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	LONP1 encodes a mitochondrial matrix protein in the Lon family of ATP dependent proteases. It binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription. Subunit: Homohexamer or homoheptamer. Organized in a ring with a central cavity. DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with PEO1 and mitochondrial DNA polymerase subunit POLG. Subcellular Location: Mitochondrion matrix. Tissue Specificity: Duodenum, heart, lung and liver, but not thymus. Similarity: Belongs to the peptidase S16 family. Contains 1 Lon domain. SWISS: P36776 Gene ID: 9361 Database links: Entrez Gene: 510796 Cow Entrez Gene: 9361 Human Entrez Gene: 74142 Mouse Entrez Gene: 170916 Rat Omim: 605490 Human SwissProt: Q59HJ6 Cow SwissProt: P36776 Human SwissProt: Q8CGK3 Mouse SwissProt: Q924S5 Rat Unigene: 350265 Human Unigene: 329136 Mouse Unigene: 146805 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (LONP1) Polyclonal Antibody, Unconjugated (SL4245R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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