Product Name	Jagged 2
Chinese Name	Notch配体Jagged 2蛋白抗体
Alias	D12Ggc2e; HJ 2; HJ2; JAG 2; JAG2; Jagged 2 precursor; Jagged2; Syndactylism.
literatures	Specific References  (3)     |     SL4244R has been referenced in 3 publications. [IF=6.291] Changjiang Liu. et al. JNK and Jag1/Notch2 co-regulate CXCL16 to facilitate cypermethrin-induced kidney damage. ECOTOX ENVIRON SAFE. 2022 Jun;238:113582  WB ;  Rat.   PubMed:35512476 [IF=5.279] Jiuyan Zhang. et al. Lycopene Alleviates Chronic Stress-Induced Spleen Apoptosis and Immunosuppression via Inhibiting the Notch Signaling Pathway in Rats. J Agr Food Chem. 2022;XXXX(XXX):XXX-XXX  WB ;  Rat.   PubMed:35212537 [IF=2.094] Yating Li. et al. Effects of Notch2 on proliferation, apoptosis and steroidogenesis in bovine luteinized granulosa cells. Theriogenology. 2021 Sep;171:55  IF,IHC ;  Cow.   PubMed:34023619
Research Area	Tumour  immunology  Neurobiology  Stem cells  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	134kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Jagged 2: 201-300/1238 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Jagged 2 is a Notch ligand involved in the mediation of Notch signaling. Jagged 2 is expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Jagged 2 is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for Jagged 2. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. Similarity: Contains 1 DSL domain. Contains 16 EGF-like domains. Contains 1 VWFC domain. SWISS: Q9Y219 Gene ID: 3714 Database links: Entrez Gene: 3714 Human Entrez Gene: 16450 Mouse Entrez Gene: 29147 Rat Omim: 602570 Human SwissProt: Q9Y219 Human SwissProt: Q9QYE5 Mouse SwissProt: P97607 Rat Unigene: 433445 Human Unigene: 22459 Rat

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