Product Name	ITPR2
Chinese Name	5-三磷酸肌醇受体2抗体
Alias	4; 5-trisphosphate receptor; Inositol 1 4 5 trisphosphate receptor type 2; Inositol 1,4,5-trisphosphate receptor type 2; Inositol 145 trisphosphate receptor type 2; InsP3 R2; InsP3R2; IP3 R2; IP3 receptor isoform 2; IP3R 2; IP3R2; ITPR 2; Itpr2; ITPR2_HUMAN; Type 2 inositol 1 4 5 trisphosphate receptor; Type 2 inositol 1; Type 2 inositol 145 trisphosphate receptor; Type 2 InsP3 receptor.
literatures	Specific References  (1)     |     SL4243R has been referenced in 1 publications. [IF=7.129] Yixin Zhang. et al. Proteomic analysis of ITPR2 as a new therapeutic target for curcumin protection against AFB1-induced pyroptosis. ECOTOX ENVIRON SAFE. 2023 Jul;260:115073  IHC ;  Mouse.   PubMed:37257342
Research Area	Tumour  immunology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	308kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ITPR2: 2351-2450/2701 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Function: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). Subunit: Homotetramer. Interacts with CABP1. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Tissue Specificity: Isoform Short is found in skeletal muscle and heart. Post-translational modifications: Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. Similarity: Belongs to the InsP3 receptor family. Contains 5 MIR domains. SWISS: Q14571 Gene ID: 3709 Database links: Entrez Gene: 281878 Cow Entrez Gene: 3709 Human Entrez Gene: 16439 Mouse Entrez Gene: 81678 Rat Omim: 600144 Human SwissProt: Q8WN96 Cow SwissProt: Q14571 Human SwissProt: Q9Z329 Mouse SwissProt: P29995 Rat Unigene: 512235 Human Unigene: 393003 Mouse Unigene: 7800 Mouse Unigene: 89152 Rat
Product Picture	Tissue/cell: mouse heart tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-ITPR2 Polyclonal Antibody, Unconjugated(SL4243R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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