Product Name	GLUT8
Chinese Name	葡萄糖Transporter8抗体
Alias	Glucose Transporter 8; Glucose transporter type 8; Glucose transporter type X1; GLUT-8; GLUT 8; GLUTX1; SLC2A8; solute carrier family 2 (facilitated glucose transporter) member 8.
literatures	Specific References  (12)     |     SL4241R has been referenced in 12 publications. [IF=4.556] Yoichi Chiba. et al. Glucose, Fructose, and Urate Transporters in the Choroid Plexus Epithelium. Int J Mol Sci. 2020 Jan;21(19):7230  IHC ;  Human.   PubMed:33008107 [IF=4.232] Paweł Jan Stanirowski. et al. Placental expression of glucose transporters GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in pregnancies complicated by gestational and type 1 diabetes mellitus.. 2021 Sep 23  IHC ;  human.   PubMed:34555239 [IF=3.584] Lin, Guan-Yu. et al. Altered glucose metabolism and its association with carbonic anhydrase 8 in Machado-Joseph Disease. METAB BRAIN DIS. 2022 Apr;:1-18  IHC ;  Mouse.   PubMed:35488942 [IF=3.23] Maria Z, Campolo AR, Lacombe VA (2015) Diabetes Alters the Expression and Translocation of the Insulin-Sensitive Glucose Transporters 4 and 8 in the Atria. PLoS ONE 10(12): e0146033.  WB ;  Mouse.   PubMed:26720696 [IF=3.23] Jackson EE, Rendina-Ruedy E, Smith BJ, Lacombe VA (2015) Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet. PLoS ONE 10(11): e0142077.  WB ;  Mouse.   PubMed:26539824 [IF=3.05] Murakami, Ryuta, et al. "Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells." Histochemistry and Cell Biology (2016):1-6.  WB, IHC-P, IHC-F ;  Human, Mouse.   PubMed:27160096 [IF=2.923] Lei Shi. et al. Proteomic analysis reveals the potential positive effects of Mito-TEMPO on ram sperm motility and fertility during cryopreservation. THERIOGENOLOGY. 2023 Jul;205:27  WB ;  Sheep.   PubMed:37084501 [IF=2.59] Tian C et al. Short communication: A high-grain diet entails alteration in nutrient chemosensing of the rumen epithelium in goats. Animal Feed Science and Technology. Volume 262, April 2020, 114410.  IHC-P ;   PubMed:doi:10.1016/j.anifeedsci.2020.114410 [IF=2.11] Mashima, Masato, et al. "Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains." Neuroscience Letters (2016).  IHC-P ;  Human.   PubMed:27818355 [IF=1.974] Changxin Tian. et al. The expression of nutrient chemosensing gate molecules in the ileum and colon is altered for goats fed on a high-grain diet. ANIM SCI J. 2022 Jan;93(1):e13754  IHC ;  Goat.   PubMed:35791780 [IF=1.58] Gao, Sujie, et al. "Propofol inhibits growth of neurons through regulating insulin receptor and insulin-like growth factor-1 receptor." Int J Clin Exp Pathol 9.7 (2016): 6785-6794.  WB ;  Rat.   PubMed:ISSN:1936-2625/IJCEP0023819 [IF=1.273] Lei Shi. et al. Effects of reduced glutathione on ram sperm parameters, antioxidant status, mitochondrial activity and the abundance of hexose transporters during liquid storage at 5 ℃. Small Ruminant Res. 2020 Aug;189:106139  WB ;  Sheep.   PubMed:10.1016/j.smallrumres.2020.106139
Research Area	Tumour  immunology  Signal transduction  Transporter  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GLUT8: 401-477/477 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Glucose transporter 8 is an insulin-regulated facilitative glucose transporter. It binds cytochalasin B in a glucose-inhibitable manner. It appears to be a dual-specific sugar transporter as it can be inhibited by fructose. It is highly expressed in testis, where it is down-regulated by estrogen, but not in testicular carcinoma. Lower amounts are present in most other tissues. Subunit: Interacts with AP2B1. Subcellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration. Insulin induces a change in the intracellular localization and gives rise to insertion in the plasma membrane. Tissue Specificity: Highest level of expression in placenta and testis. Highly expressed in adult and pubertal testis, but not prepubertal testis. Lower levels of expression in brain, liver, heart, kidney, fat and skeletal muscle. Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. SWISS: Q9NY64 Gene ID: 29988 Database links: Entrez Gene: 29988 Human Entrez Gene: 56017 Mouse Entrez Gene: 85256 Rat Omim: 605245 Human SwissProt: Q9NY64 Human SwissProt: Q9JIF3 Mouse SwissProt: Q9JJZ1 Rat Unigene: 179522 Human Unigene: 305754 Mouse Unigene: 12923 Rat
Product Picture	Sample: TM4 Cell (Mouse) Lysate at 40 ug Primary: Anti- GLUT8 (SL4241R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 52 kD Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Rat Cerebrum tissue lysates Primary: Anti-GLUT8 (SL4241R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 52 kDa

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