Product Name	ADAM17
Chinese Name	Tumour坏死因子α转换酶抗体
Alias	A disintegrin and metalloproteinase domain 17; ADAM 17; ADAM metallopeptidase domain 17; ADAM17 protein; CD 156b; CD156b; CD156b antigen; CSVP; MGC71942; Snake venom like protease; TACE; TNF alpha convertase; TNF alpha converting enzyme; Tumor Necrosis Factor Alpha Converting Enzyme; A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADA17_HUMAN.
literatures	Specific References  (6)     |     SL4236R has been referenced in 6 publications. [IF=6.961] Chan Yen-Ju. et al. Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17. FLUIDS BARRIERS CNS. 2023 Dec;20(1):1-16  WB ;  Human,Mouse.   PubMed:37095509 [IF=4.757] Maria Consiglia Trotta. et al. Oral Administration of Vitamin D3 Prevents Corneal Damage in a Knock-Out Mouse Model of Sjögren’s Syndrome. BIOMEDICINES. 2023 Feb;11(2):616  IF ;  Mouse.   PubMed:36831152 [IF=4.379] Xiao, Wenyuan. et al. Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis. Sci Rep-Uk. 2022 Mar;12(1):1-14  IF ;  Mouse.   PubMed:35288626 [IF=3.449] Haolu Sun. et al. iRhom1 rescues cognitive dysfunction in multiple sclerosis via preventing myelin injury. Genes Brain Behav. 2021 Nov;20(8):e12771  WB ;  Mouse.   PubMed:34672089 [IF=2.08] Li, Qing, et al. "Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis." Gene(2015).  WB ;   PubMed:25703701 [IF=0] Cyro José de Almeida Guardiola et al. DC-STAMP and TACE Levels are Higher in Patients with Periodontitis. Braz Dent J . Mar-Apr 2020;31(2):122-126.  WB ;  Human.   PubMed:32556010
Research Area	Tumour  immunology  Neurobiology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	68/91kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ADAM17: 201-300/824 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq]. Subunit: Interacts with MAD2L1, MAPK14 and MUC1. Subcellular Location: Membrane. Tissue Specificity: Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney. Similarity: Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. SWISS: P78536 Gene ID: 6868 Database links: Entrez Gene: 6868 Human Entrez Gene: 11491 Mouse Entrez Gene: 57027 Rat Omim: 603639 Human SwissProt: P78536 Human SwissProt: Q9Z0F8 Mouse SwissProt: Q9Z1K9 Rat Unigene: 404914 Human Unigene: 27681 Mouse Unigene: 144585 Rat
Product Picture	Sample: HepG2(Human) Cell Lysate at 30 ug Primary: Anti-ADAM17 (SL4236R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 68/93 kD Observed band size: 63/120 kD Sample: Testis (Mouse) Lysate at 40 ug Primary: Anti-ADAM17 (SL4236R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 68/93 kD Observed band size: 93/120 kD Blank control: U937 (fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti-ADAM17 antibody(SL4236R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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