Product Name	Glycerol kinase
Chinese Name	甘油激酶抗体
Alias	ATP glycerol 3 phosphotransferase; GK; GK1; GKD; Glycerokinase; Glycerol kinase; Glycerol kinase deficiency; ATP:glycerol 3-phosphotransferase; GLPK_HUMAN.
Research Area	Tumour  Cell biology  immunology  transcriptional regulatory factor  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	61kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Glycerol kinase: 21-120/559
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Glycerol kinase catalyzes the formation of glycerol 3 phosphate from ATP and glycerol. Dihydroxyacetone and L glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway. Function: Key enzyme in the regulation of glycerol uptake and metabolism. Subcellular Location: Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm. Tissue Specificity: Highly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver. DISEASE: Defects in GK are the cause of GK deficiency (GKD) [MIM:307030]. This disease can be either symptomatic with episodic metabolic and CNS decompensation or asymptomatic with hyperglycerolemia and hyperglyceroluria only. Similarity: Belongs to the FGGY kinase family. SWISS: P32189 Gene ID: 2710 Database links: Entrez Gene: 2710 Human Entrez Gene: 14933 Mouse Entrez Gene: 79223 Rat Omim: 300474 Human SwissProt: P32189 Human SwissProt: Q64516 Mouse SwissProt: Q63060 Rat Unigene: 1466 Human Unigene: 246682 Mouse Unigene: 225941 Rat

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