Product Name	IL18BP
Chinese Name	白细胞介素18Binding protein抗体
Alias	IL18 BP; IL18 BPa; IL18BP; IL18BPa; Interleukin 18 binding protein; Tadekinig alfa; I18BP_HUMAN; IL-18BP; Interleukin-18-binding protein
literatures	Specific References  (2)     |     SL4040R has been referenced in 2 publications. [IF=5.41] Businaro, Rita, et al. "Interleukin-18 modulation in autism spectrum disorders." Journal of Neuroinflammation 13.1 (2016): 2.  WB ;  Mouse.   PubMed:26728085 [IF=5.102] Serafino Ricci 2016-01-05. (2016) J.Neuroinflammation. http://www.jneuroinflammation.com/content/13/1/2  WB ;  Mouse.   PubMed:26728085
Research Area	Tumour  Cell biology  immunology  transcriptional regulatory factor  Binding protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	18kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL18BP: 91-194/194
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	IL18 binding protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18 induced IFN gamma production. It is constitutively expressed and secreted in mononuclear cells and can be enhanced by IFN gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn disease. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. Function: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. Subcellular Location: Secreted. Tissue Specificity: Strongly expressed in heart, lung, placenta and spleen. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SWISS: O95998 Gene ID: 10068 Database links: Entrez Gene: 10068 Human Entrez Gene: 84388 Rat Omim: 604113 Human SwissProt: O95998 Human Unigene: 591967 Human Unigene: 20083 Rat
Product Picture	Sample: Lane 1: Mouse Lymph node tissue lysates Lane 2: Mouse Placenta tissue lysates Lane 3: Mouse Large intestine tissue lysates Lane 4: Rat Lymph node tissue lysates Lane 5: Rat Lung tissue lysates Lane 6: Rat Placenta tissue lysates Lane 7: Rat Large intestine tissue lysates Primary: Anti-IL18BP (SL4040R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 18 kDa Observed band size: 52 kDa

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