Product Name	Steroid sulfatase
Chinese Name	类固醇硫酸酯酶抗体
Alias	ARSC; ARSC1; Arylsulfatase C; Arylsulfatase C isozyme S; ASC; EC 3.1.6.2; ES; Estrone sulfatase; SSDD; Steroid sulfatase (microsomal); Steroid sulfatase (microsomal) arylsulfatase C isozyme S; Steroid sulfatase; Steryl sulfatase; Steryl sulfatase precursor; Steryl sulfate sulfohydrolase; STS; STS_HUMAN; Steryl-sulfatase; ASC; Steryl-sulfate sulfohydrolase.
Research Area	Tumour  immunology  Chromatin and nuclear signals
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	62kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Steroid sulfatase: 51-150/583
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI). [provided by RefSeq, Jul 2008]. Function: Conversion of sulfated steroid precursors to estrogens during pregnancy. Subunit: Homodimer. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Post-translational modifications: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. DISEASE: Defects in STS are the cause of ichthyosis X-linked (IXL) [MIM:308100]. Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks. Similarity: Belongs to the sulfatase family. SWISS: P08842 Gene ID: 412 Database links: Entrez Gene: 412 Human Omim: 308100 Human SwissProt: P08842 Human Unigene: 522578 Human Unigene: 700558 Human Unigene: 700559 Human 类固醇硫酸酯酶SSDD缺乏，可导致病人的皮肤培养的纤维母细咆、滋养层细胞、外周白细胞、毛球的角化组织、表皮细胞、角质层和甲等变化，见于X连锁鱼鳞病(XLI)。
Product Picture	Sample: A431(Human) Cell Lysate at 30 ug Hela(Human) Cell Lysate at 30 ug Jurkat(Human) Cell Lysate at 30 ug Primary: Anti- Steroid sulfatase (SL3857R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 62 kD Observed band size: 63 kD Sample: Lane 1: Human A431 cell lysates Lane 2: Human HeLa cell lysates Lane 3: Human MCF-7 cell lysates Lane 4: Human 293T cell lysates Lane 5: Human SH-SY5Y cell lysates Lane 6: Human HepG2 cell lysates Primary: Anti-Steroid sulfatase (SL3857R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 62 kDa Observed band size: 60 kDa

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