Product Name	HSD17B1
Chinese Name	羟类固醇脱氢酶17β-HSD抗体
Alias	11beta-HSD1; 17beta-HSD1; 17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17β-hydroxysteroid dehydrogenasetype 1 EDH17B2; EDHB17; Estradiol 17 beta dehydrogenase 1; HSD17; Hydroxysteroid (17 beta) dehydrogenase 1; Placental 17 beta hydroxysteroid dehydrogenase; DHB1_HUMAN.
literatures	Specific References  (1)     |     SL3855R has been referenced in 1 publications. [IF=4.2] Zhang, Weidong, et al. "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." Chemosphere (2017).  IHC-P ;  Mouse.   PubMed:29202267
Research Area	Tumour  immunology  Growth factors and hormones  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	35kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HSD17B1: 21-120/328
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Subunit: Homodimer. Subcellular Location: Cytoplasm. Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. SWISS: P14061 Gene ID: 3292 Database links: Entrez Gene: 3292 Human Omim: 109684 Human SwissProt: P14061 Human Unigene: 654385 Human Unigene: 655222 Human Ⅰ型17β-羟类固醇脱氢酶又称Ⅰ型17HSD，催化雌酮与雌二醇之间的转化，为性激素合成过程中最后步骤的催化酶。它催化性激素Ｃ17位上的酮基和醇基之间的还原和氧化反应 ,使低生物活性的雌酮、雄烯二酮与高生物活性的雌二醇、睾酮之间相互转化。17βHSD的结构和功能的异常与一些疾病 ,如Tumour、假两性等的发生有密切关系.
Product Picture	Sample: MOLT-4(Human) Cell Lysate at 30 ug Primary: Anti- HSD17B1 (SL3855R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kD Observed band size: 35 kD

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