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Product Name GREB1 Chinese Name 乳腺癌雌激素调控蛋白GREB1抗体 Alias Gene regulated by estrogen in breast cancer protein; GREB 1; GREB-1; Protein GREB1; KIAA0575; GREB1_HUMAN. Research Area Tumour Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 216kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GREB1: 1851-1949/1949 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail GREB1 is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. GREB1 is expressed in proliferating prostate tissue & prostate cancer and is thought to act as a regulator of hormone-dependent cancer growth in breast and prostate cancers. Its promoter contains putative androgen receptor response elements. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Function:
May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
Subcellular Location:
Membrane; Single-pass membrane protein (Potential).
Tissue Specificity:
Expressed in proliferating prostatic tissue and prostate cancer.
Similarity:
Belongs to the GREB1 family.
SWISS:
Q4ZG55
Gene ID:
9687
Database links:Entrez Gene: 9687 Human
Entrez Gene: 268527 Mouse
Omim: 611736 Human
SwissProt: Q4ZG55 Human
SwissProt: Q3UHK3 Mouse
Unigene: 467733 Human
Unigene: 428062 Mouse
GREB1是雌激素受体调节通路中早起反应基因,在乳腺癌、前列腺癌及前列腺增生中发挥着重要的调节作用。Product Picture GREB1 Antibody (Cat. SL3854R) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the GREB1 antibody detected the GREB1 protein (arrow).
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