Product Name	Cytochrome P450 17A1
Chinese Name	细胞色素P450 17抗体
Alias	CPT7; CYP17; CYP17A1; Cytochrome P450 17A1; CYPXVII; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 XVIIA1; Cytochrome p450, subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia ; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17 alpha monooxygenase; CP17A_HUMAN.
literatures	Specific References  (10)     |     SL3853R has been referenced in 10 publications. [IF=6.71] Umehara, Takashi, et al. "The acceleration of reproductive aging in Nrg1flox/flox; Cyp19‐Cre female mice." Aging Cell (2017).  IHC-P ;  Mouse.   PubMed:28857490 [IF=6.208] Sijie Fan. et al. Seasonal Change in Adiponectin Associated with Ovarian Morphology and Function in Wild Ground Squirrels (Citellus dauricus Brandt). INT J MOL SCI. 2022 Jan;23(23):14698  IHC ;  Squirrel.   PubMed:36499026 [IF=5.194] Sijie Fan. et al. The effect of 3-Methyl-4-Nitrophenol on the early ovarian follicle development in mice by disrupting the clock genes expression. CHEM-BIOL INTERACT. 2022 May;:110001  IHC ;  Mouse.   PubMed:35654127 [IF=3.738] Li, Wanpan. et al. Exposure to Fluoride From in Utero to Puberty Alters Gonadal Structure and Steroid Hormone Expression in Offspring Rats. BIOL TRACE ELEM RES. 2022 Apr;:1-13  WB ;  Rat.   PubMed:35445938 [IF=3.188] Zeqi Tang. et al. Seasonal changes in the expression of PACAP, VPAC1, VPAC2, PAC1 and testicular activity in the testis of the muskrat (Ondatra zibethicus). EUR J HISTOCHEM. 2022 Mar 24; 66(2): 3398  IHC ;  Rat.   PubMed:35502591 [IF=2.775] Binghao Bao. et al. Zuogui Wan improves spermatogenesis of GC1-spg cells through modulating AR-related pathways. ANDROLOGIA. 2022 Apr 08  WB ;  Mouse.   PubMed:10.1111/and.14407 [IF=2.498] Huang H et al. Molecular characterization, expression and cellular localization of CYP17 gene during geese (Anser cygnoides) follicular development. Gene. 2018 Jun 5;658:184-190.  WB&IHC-P ;  Geese.   PubMed:29544766 [IF=1.951] Jisheng Wang. et al. In vitro and in vivo investigation of the therapeutic mechanism of Lycium Chinense and Cuscutae Semen on oligoasthenozoospermia. 2021 Mar 05  WB ;  Rat.   PubMed:33666949 [IF=1.858] Zihui Wang. et al. Heat stress and hypoxia inhibit the secretion of androgens and induce epithelial-to-mesenchymal transition associated with activated TGF-β/Smad signaling in canine cryptorchidism. REPROD DOMEST ANIM. 2022 Jun 09  WB ;  Dog.   PubMed:35678492 [IF=1.54] Xiyan Wang. et al. The optimized research of the in vitro culture of preantral follicles in mice. J Clin Lab Anal. 2020 Nov;34(11):e23498  WB ;  Mouse.   PubMed:33463764
Research Area	Tumour  Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	57kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CYP17: 401-508/508
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cytochrome P450 17A1 (CYP17A1) belongs to the cytochrome P450 family; it plays a role in the conversion of pregnenolone and progesterone into their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. CYP17A1 also catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. CYP17A1 is involved in sexual development during fetal life and at puberty. Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5). AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Function: Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. Subcellular Location: Membrane. Post-translational modifications: Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity. DISEASE: Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202110]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic). Similarity: Belongs to the cytochrome P450 family. SWISS: P05093 Gene ID: 1586 Database links: Entrez Gene: 493967 Cat Entrez Gene: 477807 Dog Entrez Gene: 101831170 Hamster Entrez Gene: 1586 Human Omim: 609300 Human SwissProt: Q9GMC8 Cat SwissProt: Q8HYN1 Chimpanzee SwissProt: P70687 Hamster SwissProt: Q95328 Horse SwissProt: P05093 Human Unigene: 438016 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CYP17) Polyclonal Antibody, Unconjugated (SL3853R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CYP17) Polyclonal Antibody, Unconjugated (SL3853R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. Tissue/cell: mouse embryo tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CYP17 Polyclonal Antibody, Unconjugated(SL3853R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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