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Product Name TNFRSF19 Chinese Name Tumour坏死因子配体超家族成员19抗体 Alias TROY; TAJ alpha; TAJ; TNFRSF 19; TNFRSF19; Tnfrsf20; Toxicity and JNK inducer; TRADE; Tumor necrosis factor receptor superfamily member 19. Research Area Tumour Cell biology immunology Growth factors and hormones transcriptional regulatory factor Cell Surface Molecule Immunogen Species Rabbit Clonality Polyclonal React Species Human, Guinea Pig, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 43kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TROY: 102-200/423 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail TROY is a member of the TNF receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate the JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Subunit:
Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.
Similarity:
Contains 3 TNFR-Cys repeats.
SWISS:
Q9NS68
Gene ID:
55504
Database links:Entrez Gene: 55504 Human
Entrez Gene: 29820 Mouse
Omim: 606122 Human
SwissProt: Q9NS68 Human
SwissProt: Q9JLL3 Mouse
Unigene: 149168 Human
Unigene: 730848 Human
Unigene: 281356 Mouse
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