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Product Name TNFSF9 Chinese Name Tumour坏死因子配体超家族成员9抗体 Alias Tumor necrosis factor ligand superfamily member 9; CD137L; TNLG5A; 4 1BB L; 4-1BB-L; 4 1BB ligand; 4 1BBL; CD137 ligand; homolog of mouse 4 1BB L; homolog of mouse 4 1BBL; ILA ligand (TNF related); Ly63l; receptor 4 1BB ligand; Tumor necrosis factor (ligand) superfamily member 9; receptor 4-1BB ligand; tumor necrosis factor ligand 5A; TNFL9_HUMAN; Research Area Tumour Cell biology immunology Neurobiology Cell Surface Molecule t-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 25-27kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TNFSF9: 101-200/254 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This cytokine belongs to the tumour necrosis factor (TNF) ligand family. It is a ligand for TNFRSF9, which is a costimulatory molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process, and in the generation of cytotoxic T cells. This cytokine is also shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is found to be expressed in various carcinoma cell lines, and is thought to be involved in T cell-tumour cell interaction.
Function:
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Subunit:
Homotrimer.
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Tissue Specificity:
Expressed in brain, placenta, lung, skeletal muscle and kidney.
Similarity:
Belongs to the tumor necrosis factor family.
SWISS:
P41273
Gene ID:
8744
Database links:Entrez Gene: 8744 Human
Omim: 606182 Human
SwissProt: P41273 Human
Unigene: 1524 Human
Product Picture Sample:
Cerebrum (Rat) Lysate at 40 ug
Primary: Anti-CD137L(SL3851R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 25-27 kD
Observed band size: 27 kD
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