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Product Name TSC1 Chinese Name 结节性硬化症蛋白1抗体 Alias LAM; Hamartin; Tuberous sclerosis 1 protein; TSC1_HUMAN; KIAA0243; TSC; Tuberous sclerosis 1. literatures Specific References (2) | SL3837R has been referenced in 2 publications.[IF=4.8] Cao, Jiaxue, et al. "DNA methylation Landscape of body size variation in sheep." Scientific reports 5 (2015). WB ; Sheep.[IF=3.14] Wang, Yuanyuan, et al. "Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation." International Journal of Biological Macromolecules (2016). IHC-P ; Mouse.Research Area Tumour Cell biology Chromatin and nuclear signals Cyclin transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 130 kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Hamartin: 131-230/1164 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.
Function:
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
Subunit:
Interacts with TSC2, leading to stabilize TSC2. In the absence of TSC2, TSC1 self-aggregates. Interacts with DOCK7. Interacts with FBXW5 and TBC1D7.
Subcellular Location:
Cytoplasm. Membrane. At steady state found in association with membranes.
Tissue Specificity:
Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells.
Post-translational modifications:
Phosphorylation at Ser-505 does not affect interaction with TSC2. Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:
Defects in TSC1 are the cause of tuberous sclerosis type 1 (TSC1) [MIM:191100]. It is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. TS1C is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination). Clinical symptoms can range from benign hypopigmented macules of the skin to profound mental retardation with intractable seizures to premature death from a variety of disease-associated causes.
Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC) [MIM:607341]. FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.
SWISS:
Q92574
Gene ID:
7248
Database links:Entrez Gene: 7248 Human
Entrez Gene: 64930 Mouse
Omim: 605284 Human
SwissProt: Q92574 Human
SwissProt: Q9EP53 Mouse
Unigene: 370854 Human
Unigene: 224354 Mouse
Unigene: 205837 Rat
结节性硬化症为常染色体显性遗传,也常见散发病例。是Tumour抑制基因,基因产物分别为Hamartin和tuberin,两者均调节细胞生长。
结节性硬化症(tuberous sclerosis)又称结节性脑硬化,Bourneville病。本病可归类于神经皮肤综合征(亦称斑痣性错构瘤病),是源于外胚层的器官发育异常所致,病变累及神经系统、皮肤和眼,也可累及中胚层,内胚层器官如心、肺、骨,肾和胃肠等。皮脂腺瘤是皮肤神经末梢、增生的结缔组织和血管组成,视网膜可见胶质瘤、神经节细胞瘤,心、肾、肺、肝脏等也可发生Tumour。
而神经胶质增生性硬化结节广泛发生于大脑皮质、白质、基底节和室管膜下,常伴钙质沉积,可出现一位症及血管增生等,出现癫痫发作及智能减退为特征。
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