Product Name	GDF15
Chinese Name	生长分化因子15/巨嗜细胞抑制因子1抗体
Alias	GDF 15; GDF-15; GDF15_HUMAN; Growth differentiation factor 15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC 1; Mic-1; MIC1; NAG 1; NAG-1; NAG1; NRG 1; NRG-1; NRG1; NSAID (nonsteroidal anti inflammatory drug) activated protein 1; NSAID; NSAID regulated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; Placental bone morphogenetic protein; Placental bone morphogenic protein; Placental TGF beta; Placental TGF-beta; Prostate differentiation factor; PTGF beta; PTGFB.
literatures	Specific References  (9)     |     SL3818R has been referenced in 9 publications. [IF=7.561] Huan Li. et al. The Clinical Value of GDF15 and Its Prospective Mechanism in Sepsis. Front Immunol. 2021; 12: 710977  WB ;  human.   PubMed:34566964 [IF=6.429] Sugimoto Mitsuru. et al. Clinical usefulness and acceleratory effect of macrophage inhibitory cytokine-1 on biliary tract cancer: an experimental biomarker analysis. CANCER CELL INT. 2022 Dec;22(1):1-15  IHC ;  Human.   PubMed:35948981 [IF=5.29] Ueno, Koji, et al. "Increased plasma VEGF levels following ischemic preconditioning are associated with downregulation of miRNA-762 and miR-3072-5p." Scientific Reports 6 (2016): 36758.  WB ;  Mouse.   PubMed:27905554 [IF=4.736] Xu Guanlan. et al. Deletion of Gdf15 Reduces ER Stress-induced Beta-cell Apoptosis and Diabetes. ENDOCRINOLOGY. 2022 May;163(5):  WB ;  Mouse.   PubMed:35290443 [IF=4.6] Figueiredo, Jose-Luiz, et al. "Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice with Chronic Renal Disease." The American Journal of Pathology (2015).  IHC-F ;  Mouse.   PubMed:25680278 [IF=4.447] Juan Zhang. et al. DHODH inhibition modulates glucose metabolism, circulating GDF15 and improves metabolic balance. Iscience. 2021 May;:102494   PubMed:34113829 [IF=3.269] Mengxue Zhang. et al. Identification and validation of potential novel biomarkers for oral squamous cell carcinoma. Bioengineered. 2021;12(1):8845-8862  IF,IHC ;  Human,Mouse.   PubMed:34606406 [IF=1.89] Li, Yun-Long, et al. "Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer." International Journal of Clinical and Experimental Pathology 8.7 (2015): 8136.  WB ;  Human.   PubMed:26339382 [IF=1.42] Ruan, Wei-Min, et al. "Differential expression of glycoprotein non-metastatic melanoma protein B (GPNMB) involved in trichostatin A-induced apoptosis in gastric cancer." International journal of clinical and experimental medicine 7.12 (2014): 4857-4866.  IHC-P ;  Human.   PubMed:25663982
Research Area	Cardiovascular  Cell biology  Signal transduction  Cyclin  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	12.5/34kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GDF-15: 221-308/308
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53. Subcellular Location: Secreted. Tissue Specificity: Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney. Similarity: Belongs to the TGF-beta family. SWISS: Q99988 Gene ID: 9518 Database links: Entrez Gene: 9518 Human Entrez Gene: 23886 Mouse Entrez Gene: 29455 Rat Omim: 605312 Human SwissProt: Q99988 Human SwissProt: Q9Z0J7 Mouse SwissProt: Q9Z0J6 Rat Unigene: 616962 Human Unigene: 31325 Mouse Unigene: 44228 Rat 生长分化因子15（GDF15）是骨形态发生蛋白（BMP）和转化生长因子-β超家族成员。GDF-15又叫巨噬细胞抑制因子（macrophage inhibiting cytokine，MIC）-1、胎盘转化生长因子 （placental transformation growth factor，PTGF）-β、前列腺衍生因子（prostate derived factor，PDF）和胎盘骨形态发生蛋白（placental bone morphogeneticprotein，PLAB）。 有学者认为：GDF-15在Tumour发展的不同阶段发挥着不同的生物学作用；随着Tumour的发生发展，GDF-15可能表达不同形式的蛋白，在Tumour发生的早期阶段可能发挥抑瘤作用，而在Tumour发展的后期阶段发挥促瘤作用。
Product Picture	Sample: Lane 1: Urinary bladder (Mouse) Lysate at 40 ug Lane 2: Large intestine (Mouse) Lysate at 40 ug Lane 3: Urinary bladder (Rat) Lysate at 40 ug Lane 4: Large intestine (Rat) Lysate at 40 ug Lane 5: HT1080 (Human) cell Lysate at 40 ug Lane 6: HepG2 (Human) cell Lysate at 40 ug Lane 7: K562 (Human) cell Lysate at 40 ug Lane 8: A549 (Human) cell Lysate at 40 ug Primary: Anti-GDF15 (SL3818R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kD Observed band size: 35 kD Sample: K562 Cell Lysate at 30 ug A431 Cell Lysate at 30 ug Primary: Anti-GDF15 (SL3818R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(SL0295G-HRP) at 1: 5000 dilution; Predicted band size:34 kD Observed band size:30 kD Paraformaldehyde-fixed, paraffin embedded (Mouse placenta); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (GDF15) Polyclonal Antibody, Unconjugated (SL3818R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.

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