Product Name	Claudin 6
Chinese Name	紧密连接蛋白6抗体
Alias	Claudin6; CLDN 6; CLDN6; Skullin 2; CLD6_HUMAN; Claudin-6; Claudin 6; OTTHUMP00000159248; Skullin-2; Skullin; UNQ757/PRO1488.
literatures	Specific References  (1)     |     SL3754R has been referenced in 1 publications. [IF=1.205] Yosuke Morizawa. et al. Sodium plays an important role in the absorption of intravesical fluid. Luts. 2021 Jan;13(1):177-182  IHC ;  Rat.   PubMed:32410367
Research Area	Tumour  Cell biology  immunology  The cell membrane受体  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Horse, Rabbit, Guinea Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Claudin 6: 111-220/220 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010] Function: Plays a major role in tight junction-specific obliteration of the intercellular space. Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Subcellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the claudin family. SWISS: P56747 Gene ID: 9074 Database links: Entrez Gene: 9074 Human Entrez Gene: 54419 Mouse SwissProt: P56747 Human SwissProt: Q9Z262 Mouse Unigene: 533779 Human Unigene: 485133 Mouse Unigene: 86421 Mouse

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