Product Name	Nox1
Chinese Name	有丝分裂氧化酶1抗体
Alias	Mitogenic oxidase 1; MOX1; NADH/NADPH mitogenic oxidase subunit P65 MOX; NADPH oxidase 1; NADPH oxidase 1 variant NOH 1L; NADPH oxidase homolog 1; NOH 1; NOH1; RP1-146H21.1; GP91-2; Mitogenic oxidase (pyridine nucleotide dependent superoxide generating).
literatures	Specific References  (9)     |     SL3682R has been referenced in 9 publications. [IF=9.038] Xie C et al. Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK. J Hazard Mater . 2020 Jul 15;394:122549.  WB，IF ;  mouse.   PubMed:32283380 [IF=8.401] Mr. Aleksandr Vendrov. et al. Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension. 2021 Oct 29  IF,IHC ;  Mouse.   PubMed:34714114 [IF=6.1] Yun, Yang, et al. "Sulfate Aerosols Promote Lung Cancer Metastasis by Epigenetically Regulating the Epithelial-to-Mesenchymal Transition (EMT)." Environmental Science & Technology (2017).  WB ;  Human.   PubMed:28901751 [IF=5.307] Xu Zhou. et al. Magnesium isoglycyrrhizinate ameliorates lipopolysaccharide-induced liver injury by upregulating autophagy and inhibiting inflammation via IL-22 expression. BIOORG CHEM. 2022 Nov;128:106034  IHC ;  Mouse.   PubMed:35908353 [IF=5.243] Peng Ding. et al. BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3-Akt-Nrf2 pathway. 2021 Dec 14  WB ;  Mouse.   PubMed:34904361 [IF=4.96] Xue-Qi Liuet al. Rutaecarpine Derivative Cpd-6c Alleviates Acute Kidney Injury by Targeting PDE4B, a Key Enzyme Mediating inflammation in Cisplatin Nephropathy. Biochem Pharmacol . 2020 Oct;180:114132.  WB ;   PubMed:32622666 [IF=3.448] Ma Q et al. Non‐coenzyme role of vitamin B1 in RANKL‐induced osteoclastogenesis and ovariectomy induced osteoporosis. J Cell Biochem. 2020 Feb 26.  WB ;  mouse.   PubMed:32100911 [IF=2.766] Bourmoum et al. The GTPase ARF6 Controls ROS Production to Mediate Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation. (2016) PLoS.One. 11:e0148097  WB ;  Rat.   PubMed:26824355 [IF=1.25] Kashiwabara, Yoshiaki, et al. "Immunohistochemical localization of Nox in mouse circumvallate papillae." Tissue and Cell (2015).  IHC-P ;  Mouse.   PubMed:26603975
Research Area	immunology  Kinases and Phosphatases  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	62kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Nox1: 425-515/515 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The NOX family NADPH protein oxidases are involved in transfer of electrons accross membranes to generate reactive oxygen species. There are 7 family members - NOX1-5, DUOX1 and DUOX2. Expression of NOX1 is highest in colon tissue; it is also found in vascular tissue and can also been induced by a variety of factors including PDGF. It requires interaction with NOXO1 and NOXA1 for superoxide generation. Subunit: NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts with NOXA1 and NOXO1. Subcellular Location: Cell projection, invadopodium membrane; Multi-pass membrane protein. Tissue Specificity: NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells. Similarity: Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain. SWISS: Q9Y5S8 Gene ID: 27035 Database links: Entrez Gene: 27035 Human Entrez Gene: 237038 Mouse Omim: 300225 Human SwissProt: Q9Y5S8 Human SwissProt: Q8CIZ9 Mouse Unigene: 592227 Human Unigene: 233865 Mouse
Product Picture	Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-Nox1 (SL3682R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 62 kD Observed band size: 62 kD Sample: Testis (Mouse) Lysate at 40 ug Uterus (Mouse) Lysate at 40 ug DU145(Human) Cell Lysate at 30 ug Primary: Anti- Nox1 (SL3682R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 62 kD Observed band size: 60 kD Sample: Testis (Mouse) Lysate at 40 ug Primary: Anti- Nox1 (SL3682R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/10000 dilution Predicted band size: 62 kD Observed band size: 57 kD

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