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Product Name HRH3 Chinese Name 组织胺H3受体抗体 Alias G protein coupled receptor 97; GPCR 97; GPCR97; H3R; HH 3R; HH3 R; HH3R; Histamine H3 receptor; Histamine receptor H3; HRH 3; HRH3; HRH-3. literatures Specific References (2) | SL3635R has been referenced in 2 publications.[IF=11.685] Kristine Elisabeth Eberhard. et al. Neurotransmitter and Neurotransmitter Receptor Expression in the Saccule of the Human Vestibular System. Prog Neurobiol. 2022 Jan;:102238 IHC ; Human.[IF=1.54] Møller, M. Nue, et al. "Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease." European Archives of Oto-Rhino-Laryngology: 1-6. IHC-P ; Human.Research Area Tumour Cell biology immunology Signal transduction transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Cow, Horse, ) Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 49kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HRH3/GPCR97: 121-220/445 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008].
Function:
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
Q9Y5N1
Gene ID:
11255
Database links:Entrez Gene: 11255 Human
Entrez Gene: 99296 Mouse
Omim: 604525 Human
SwissProt: Q9Y5N1 Human
SwissProt: P58406 Mouse
Unigene: 251399 Human
Unigene: 285360 Mouse
Unigene: 7617 Rat
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