TEL: +86 571 56623320 EMAIL: [email protected]
Product Name HBEGF Chinese Name 肝素结合性表皮生长因子抗体 Alias HB EGF; Diphtheria toxin receptor; DT R; DT-R; DTR; DTS; DTSF; HB-EGF; HBEGF_HUMAN; HEGFL; heparin binding EGF like growth factor; Heparin binding epidermal growth factor; Heparin binding epidermal growth factor like growth factor; Heparin-binding EGF-like growth factor; Proheparin binding EGF like growth factor. literatures Specific References (3) | SL3576R has been referenced in 3 publications.[IF=12.121] Maximilian Strunzet al. Alveolar regeneration through a Krt8+ transitional stem cell state that persists in Human lung fibrosis. Nat Commun . 2020 Jul 16;11(1):3559. IF ; mouse.[IF=4.61] Lebkuechner et al. Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency. (2015) J.Neurochem. 135:234-48 ICC ; Mouse.[IF=4.28] Lebkuechner, Isabell, et al. "Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency." Journal of Neurochemistry(2015). Mouse.Research Area Tumour Cardiovascular immunology Signal transduction Growth factors and hormones vascular endothelial cell Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 21kDa Cellular localization The cell membrane Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HB-EGF: 51-150/208 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a 22kDa O-glycosylated protein that is a potent mitogen and chemoattractant for vascular smooth muscle cells, fibroblasts and epithelial cells but not endothelial cells. The natural protein has an apparent molecular mass of 19-23 kDa and exists in multiple forms as a result of heterogeneous O-glycosylation and/or Nterminal truncation. HB-EGF is synthesized as a membrane-anchored precursor(proHB-EGF) that is proteolytically cleaved to release the soluble mature growth factor. The two forms are active as juxtacrine and paracrine/autocrine growth factors respectively.HB-EGF activates two EGF receptor subtypes, HER1/ErbB1 and HER4 and binds to heparan sulfate proteoglycan.
Function:
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Subunit:
Interacts with FBLN1. Interacts with EGFR and ERBB4.
Subcellular Location:
Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.
Proheparin-binding EGF-like growth factor: Cell membrane; Single-pass type I membrane protein.
Post-translational modifications:
Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.
O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44.
Similarity:
Contains 1 EGF-like domain.
SWISS:
Q99075
Gene ID:
1839
Database links:Entrez Gene: 1839 Human
Omim: 126150 Human
SwissProt: Q99075 Human
Unigene: 799 Human
Scan Wechat Qrcode