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Product Name Phospho-NCF4 (Thr154) Chinese Name 磷酸化嗜中性粒细胞胞浆因子4抗体 Alias NCF4 (phospho T154); p- NCF4 (phospho T154); p40phox (Thr154); p-p40phox (Thr154); MGC3810; NCF 4; NCF; NCF-4; Ncf4; NCF4_HUMAN; Neutrophil cytosol factor 4; Neutrophil cytosolic factor 4; Neutrophil NADPH oxidase factor 4; p40-phox; p40phox; SH3 and PX domain-containing protein 4. Product Type Phosphorylated anti Research Area Tumour Cell biology immunology Signal transduction TumourCell biologyMaker The new supersedes the old Mitochondrion Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Rabbit, Guinea Pig, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 39kDa Cellular localization cytoplasmic Mitochondrion Form Liquid Concentration 1mg/ml immunogen KLH conjugated Synthesised phosphopeptide derived from human p40phox around the phosphorylation site of Thr154: PR(p-T)RK Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail NCF4 is a cytosolic oxidase associated protein. It is a component of the nicotinamide adenine dinucleotide phosphate oxidase, which mediates down regulation of NADPH oxidase through interactions with its SH3 domain. NCF4 is associated with p67 phox but is absent in patients with chronic granulomatous disease who lack p67 phox.
Function:
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
Subunit:
p40-PHOX associates primarily with p67-PHOX to form a complex with p47-PHOX.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expression is restricted to hematopoietic cells.
DISEASE:
Granulomatous disease, chronic, cytochrome-b-positive 3, autosomal recessive (CGD3) [MIM:613960]: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Contains 1 OPR domain.
Contains 1 PX (phox homology) domain.
Contains 1 SH3 domain.
SWISS:
Q15080
Gene ID:
4689
Database links:Entrez Gene: 4689 Human
Entrez Gene: 17972 Mouse
Omim: 601488 Human
SwissProt: Q15080 Human
SwissProt: P97369 Mouse
Unigene: 474781 Human
Unigene: 2068 Mouse
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