Product Name	Phospho-TCTP (Ser46)
Chinese Name	磷酸化翻译控制Tumour蛋白抗体
Alias	TCTP (Phospho Ser46); TCTP (Phospho S46); Fortilin; Histamine-releasing factor; p02; p23; TPT1; translationally controlled tumor protein; tumor protein translationally-controlled 1; TCTP_HUMAN.
Product Type	Phosphorylated anti
Research Area	Tumour  Cell biology  immunology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	20kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human TCTP around the phosphorylation site of Ser46: DD(p-S)LI
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TCTP is involved in calcium binding and microtubule stabilization. It is an immunoglobulin E dependent histamine-releasing factor produced by lymphocytes of atopic children and present in biologic fluids of allergic patients. Both human and mouse recombinant HRF proteins caused histamine release from human basophils of a subpopulation of donors (referenced from OMIM). Function: Involved in calcium binding and microtubule stabilization. Subunit: Interacts with STEAP3. Subcellular Location: Cytoplasm. Tissue Specificity: Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate. Similarity: Belongs to the TCTP family. SWISS: P13693 Gene ID: 7178 Database links: Entrez Gene: 7178 Human Entrez Gene: 22070 Mouse Entrez Gene: 116646 Rat Omim: 600763 Human SwissProt: P13693 Human SwissProt: P63028 Mouse SwissProt: P63029 Rat Unigene: 374596 Human Unigene: 296922 Mouse Unigene: 297482 Mouse Unigene: 36610 Rat 翻译控制Tumour蛋白最初发现于Tumour组织，后来又从其他组织中相继分离出来,是许多动物Tumour细胞中存在的一类较丰富的蛋白,TCTP参与钙离子结合和微管的稳定,是一类广泛存在于动物、Botany及酵母中的、在序列上高度保守且具有很高表达量的蛋白家族。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Phospho-TCTP (Ser46)) Polyclonal Antibody, Unconjugated (SL3422R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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