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Product Name CRHR1 Chinese Name 促肾上腺皮质释放激素受体1抗体 Alias CRF1; Corticotropin releasing hormone receptor variant 1h;CRF-RI; CRF 1; CRF R; CRFR1; CRH R1h; CRF-R1; CRHR 1; CRHR; CRHR1; CRHR1f; Releasing hormone receptor 1; Seven transmembrane helix receptor; corticotropin releasing hormone receptor 1; Crhr1; Crhr; MGC124237; MGC124240; CRF-R; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1; CRH-R1h; CRHR; CRHR1L; CRFR1_HUMAN. literatures Specific References (4) | SL2791R has been referenced in 4 publications.[IF=5.878] Junlong Li. et al. Orcinol glucoside improves the depressive-like behaviors of perimenopausal depression mice through modulating activity of hypothalamic–pituitary–adrenal/ovary axis and activating BDNF- TrkB-CREB signaling pathway. 2021 Aug 11 WB ; Mouse.[IF=4.122] Harlé et al. Murine splenic B cells express corticotropin-releasing hormone receptor 2 that affect their viability during a stress response. (2018) Sci.Rep. 8:143 WB,IF&IHC ; Mouse.[IF=2.17] Zhu, Xiaoxia, et al. "Xiao Yao San improves depressive-like behavior in rats through modulation of β-arrestin 2 mediated pathways in hippocampus." Evid Based Complement Alternat Med.2014:902516 WB ; Rat.[IF=1.759] Hashimoto,et al.The Effect of a High-Fat Diet on the Development of Abdominal Aortic Aneurysm in a Vascular Hypoperfusion-Induced Animal Model.(2018) Journal of Vascular Research. 55:63-74. IHC-F ; Rat.Research Area Tumour Cell biology immunology Neurobiology Growth factors and hormones Endocrinopathy Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, Applications WB= IHC-P=1:100-500 IHC-F=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 48kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CRHR1/CRFR1: 301-400/444 <Cytoplasmic> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants one of which is a non-coding read-through transcript with the neighboring gene MGC57346.
Function:
Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subunit:
Interacts (via N-terminal extracellular domain) with CRF and UCN.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.
Post-translational modifications:
C-terminal Ser or Thr residues may be phosphorylated.
Similarity:
Belongs to the G-protein coupled receptor 2 family.
SWISS:
P34998
Gene ID:
1394
Database links:Entrez Gene: 1394 Human
Entrez Gene: 12921 Mouse
Omim: 122561 Human
SwissProt: P34998 Human
SwissProt: P35347 Mouse
Unigene: 417628 Human
Unigene: 1892 Mouse
Unigene: 10499 Rat
Product Picture Sample:
Lane 1: Cerebrum (Mouse) Lysate at 40 ug
Lane 2: Cerebellum (Mouse) Lysate at 40 ug
Lane 3: Testis (Mouse) Lysate at 40 ug
Lane 4: Cerebrum (Rat) Lysate at 40 ug
Lane 5: Cerebellum (Rat) Lysate at 40 ug
Primary: Anti-CRHR1 (SL2791R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50-55 kD
Observed band size: 48 kD
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