Product Name	CRHR1
Chinese Name	促肾上腺皮质释放激素受体1抗体
Alias	CRF1; Corticotropin releasing hormone receptor variant 1h;CRF-RI; CRF 1; CRF R; CRFR1; CRH R1h; CRF-R1; CRHR 1; CRHR; CRHR1; CRHR1f; Releasing hormone receptor 1; Seven transmembrane helix receptor; corticotropin releasing hormone receptor 1; Crhr1; Crhr; MGC124237; MGC124240; CRF-R; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1; CRH-R1h; CRHR; CRHR1L; CRFR1_HUMAN.
literatures	Specific References  (4)     |     SL2791R has been referenced in 4 publications. [IF=5.878] Junlong Li. et al. Orcinol glucoside improves the depressive-like behaviors of perimenopausal depression mice through modulating activity of hypothalamic–pituitary–adrenal/ovary axis and activating BDNF- TrkB-CREB signaling pathway. 2021 Aug 11  WB ;  Mouse.   PubMed:34382261 [IF=4.122] Harlé et al. Murine splenic B cells express corticotropin-releasing hormone receptor 2 that affect their viability during a stress response. (2018) Sci.Rep. 8:143  WB,IF&IHC ;  Mouse.   PubMed:29317694 [IF=2.17] Zhu, Xiaoxia, et al. "Xiao Yao San improves depressive-like behavior in rats through modulation of β-arrestin 2 mediated pathways in hippocampus." Evid Based Complement Alternat Med.2014:902516  WB ;  Rat.   PubMed:25097660 [IF=1.759] Hashimoto,et al.The Effect of a High-Fat Diet on the Development of Abdominal Aortic Aneurysm in a Vascular Hypoperfusion-Induced Animal Model.(2018) Journal of Vascular Research. 55:63-74.  IHC-F ;  Rat.   PubMed:29393228
Research Area	Tumour  Cell biology  immunology  Neurobiology  Growth factors and hormones  Endocrinopathy
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB= IHC-P=1:100-500 IHC-F=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	48kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CRHR1/CRFR1: 301-400/444 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants one of which is a non-coding read-through transcript with the neighboring gene MGC57346. Function: Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Subunit: Interacts (via N-terminal extracellular domain) with CRF and UCN. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. Post-translational modifications: C-terminal Ser or Thr residues may be phosphorylated. Similarity: Belongs to the G-protein coupled receptor 2 family. SWISS: P34998 Gene ID: 1394 Database links: Entrez Gene: 1394 Human Entrez Gene: 12921 Mouse Entrez Gene: 58959 Rat Omim: 122561 Human SwissProt: P34998 Human SwissProt: P35347 Mouse SwissProt: P35353 Rat Unigene: 417628 Human Unigene: 1892 Mouse Unigene: 10499 Rat
Product Picture	Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ug Lane 2: Cerebellum (Mouse) Lysate at 40 ug Lane 3: Testis (Mouse) Lysate at 40 ug Lane 4: Cerebrum (Rat) Lysate at 40 ug Lane 5: Cerebellum (Rat) Lysate at 40 ug Primary: Anti-CRHR1 (SL2791R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50-55 kD Observed band size: 48 kD

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Totalgoods,subtotals:￥Checkout