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Product Name DDAH2 Chinese Name 双甲基精氨酸水解酶2抗体 Alias DDAH; DDAHII; DDAH II; Dimethylargininase 2; DDAH2_HUMAN; AH2; DDAH 2; DDAH-2; Dimethylarginine Dimethylaminohydrolase 2; Dimethylaminohydrolase II; N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; NG dimethylarginine dimethylamino hydrolase homolog; G6a; NG30; Protein G6a; S phase protein. Research Area Tumour Cardiovascular Cell biology immunology Neurobiology Immunogen Species Rabbit Clonality Polyclonal Clone NO. H9G41 React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 30kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human DDAH2: 41-140/285 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]
Function:
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
Tissue Specificity:
Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain.
Similarity:
Belongs to the DDAH family.
SWISS:
O95865
Gene ID:
23564
Database links:Entrez Gene: 23564 Human
Entrez Gene: 51793 Mouse
Omim: 604744 Human
SwissProt: O95865 Human
SwissProt: Q99LD8 Mouse
Unigene: 247362 Human
Unigene: 1457 Mouse
Unigene: 203056 Rat
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