Product Name	SLAMF6/LY108
Chinese Name	SLAMF6抗体
Alias	LY108; Activating NK receptor; KALI; KALIb; MGC104953; NK T B antigen; NTB A; NTBA; SF2000; SLAM family member 6; SLAM family member 6 precursor; SLAMF6; SLAF6_HUMAN; NK-T-B-antigen; NTB-A; CD352.
Research Area	immunology  Cell Surface Molecule  Cell type markers  Natural killer cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	37kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse SLAMF6: 51-150/331
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. It may play a role in the regulation of autoimmune diseases. Function: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. Subunit: Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Subcellular Location: Cell membrane; Single-pass type I membrane protein (Probable). Tissue Specificity: Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. Similarity: Contains 1 Ig-like (immunoglobulin-like) domain. SWISS: Q9ET39 Gene ID: 30925 Database links: Entrez Gene: 114836 Human Entrez Gene: 30925 Mouse Omim: 606446 Human SwissProt: Q96DU3 Human SwissProt: Q9ET39 Mouse Unigene: 492348 Human Unigene: 486404 Mouse
Product Picture	Sample: Lymph node (Mouse) Lysate at 40 ug Primary: Anti-LY108 (SL2682R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 37 kD Observed band size: 48 kD

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