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Product Name CD112 Chinese Name Cell adhesion moleculeCD112抗体 Alias Nectin-2; Nectin2; Nectin 2; CD 112; CD112 antigen; Herpes virus entry mediator B; Herpes virus entry protein B; Herpesvirus entry mediator B; Herpesvirus entry protein B; Hve B; HveB; Poliovirus receptor like 2; Poliovirus receptor related 2 (herpesvirus entry mediator B); Poliovirus receptor related 2; Poliovirus receptor related protein 2; Poliovirus receptor-related protein 2; Nectin cell adhesion molecule 2; HVEB; PRR 2; PRR2; PVRL 2; PVRL2; NECT2_HUMAN; PVRR 2; PVRR2. literatures Specific References (1) | SL2679R has been referenced in 1 publications.[IF=1.45] Waters, Alicia M., et al. "Effect of Repeat Dosing of Engineered Oncolytic Herpes Simplex Virus on Preclinical Models of Rhabdomyosarcoma." Translational Oncology 9.5 (2016): 419-430. WB ; Human.Research Area Tumour immunology Neurobiology Cell adhesion molecule Cell Surface Molecule endothelial cells Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Cow, Horse, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 56kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CD112: 251-350/538 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Nectin 2 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Can form trans-heterodimers with PVRL3/nectin-3.
Function:
Probable cell adhesion protein.
Subunit:
Can form trans-heterodimers with PVRL3/nectin-3. Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
Q92692
Gene ID:
5819
Database links:Entrez Gene: 5819 Human
Entrez Gene: 19294 Mouse
Omim: 600798 Human
SwissProt: Q92692 Human
SwissProt: P32507 Mouse
Unigene: 655455 Human
Unigene: 4341 Mouse
Unigene: 203297 Rat
Cell adhesion moleculeNectin-2(CD112)是一种同源性非钙依赖型的CAM,属免疫球蛋白超家族,由nectin-1、nectin-2、nectin-3组成,广泛存在于Tumour、正常细胞,神经细胞、endothelial cells等,CD112也是单纯疱疹病毒(HSV-1和HSV-2)的受体,具有同型或异型细胞粘附活性.在多发性硬化中呈现高表达。Product Picture Blank control(blue): U937(fixed with 2% paraformaldehyde (10 min)).
Primary Antibody:Rabbit Anti-CD112 antibody(SL2679R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
econdary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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