Product Name	MARCO
Chinese Name	巨噬细胞清道夫受体抗体
Alias	Macrophage receptor MARCO; Marco; MARCO_HUMAN; Macrophage receptor with collagenous structure; SCARA2; Scavenger receptor class A member 2.
literatures	Specific References  (2)     |     SL2659R has been referenced in 2 publications. [IF=12.57] Li, Hao, et al. "Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus." The Journal of clinical investigation 125.7 (2015): 2877.  IHC-P ;  Human.   PubMed:26098211 [IF=3.329] Xiao Y et al. Down-regulation of MARCO associates with tumor progression in hepatocellular carcinoma. Exp Cell Res. 2019 Aug 2:111542.  WB&IHC-P ;  Human.   PubMed:31381879
Research Area	Cell biology  immunology  Microbiology  Bacteria and viruses
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Guinea Pig,  (predicted: Rat, Chicken, Dog, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MARCO: 421-520/520 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq]. Function: Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria. Subunit: Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands. Subcellular Location: Membrane; Single-pass type II membrane protein. Similarity: Contains 1 collagen-like domain. Contains 1 SRCR domain. SWISS: Q9UEW3 Gene ID: 8685 Database links: Entrez Gene: 8685 Human Omim: 604870 Human SwissProt: Q9UEW3 Human Unigene: 67726 Human
Product Picture	Tissue/cell: mouse lung tissue;4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-MARCO Polyclonal Antibody, Unconjugated(SL2659R-FITC) 1:100, overnight at 4°C; DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei

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