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Product Name SPHK1, Alexa Fluor 750 conjugated Chinese Name AF750标记的鞘氨醇激酶1抗体 Alias sphingosine kinase 1; SK 1; SK1; SPHK 1; SPHK; SPK; SPK 1; SPK1; Sphk1; SPHK1_HUMAN. Research Area Tumour Cell biology Signal transduction Apoptosis Kinases and Phosphatases Cell differentiation Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, ) Applications IF=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 42-52kDa Cellular localization The nucleus cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SPHK1: 1-100/384 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
SWISS:
Q9NYA1
Gene ID:
8877
Database links:Entrez Gene: 8877 Human
Entrez Gene: 20698 Mouse
Omim: 603730 Human
SwissProt: Q9NYA1 Human
SwissProt: Q8CI15 Mouse
Unigene: 68061 Human
Unigene: 20944 Mouse
Unigene: 18522 Rat
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