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Product Name IL17F Chinese Name 白介素-17F抗体 Alias Interleukin 17F; Cytokine ML-1; IL-17F; IL17F_HUMAN; Interleukin-17F; CANDF6; ML1. Research Area Cell biology immunology Cell Surface Molecule t-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 17kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human IL-17F: 71-163/163 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
Function:
Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.
Subunit:
Homodimer; disulfide-linked.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
DISEASE:
Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6) [MIM:613956]. CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Similarity:
Belongs to the IL-17 family.
SWISS:
Q96PD4
Gene ID:
112744
Database links:Entrez Gene: 112744 Human
Omim: 606496 Human
SwissProt: Q96PD4 Human
Unigene: 272295 Human
Product Picture Sample:
RAW264.7 (Mouse)Cell Lysate at 30 ug
Jurkat(Human) Cell Lysate at 30 ug
HL-60(Human) Cell Lysate at 30 ug
LOVO(Human) Cell Lysate at 30 ug
Primary: Anti-IL17F (SL2614R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 17 kD
Observed band size: 22 kD
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