Product Name	IL-18R alpha
Chinese Name	白细胞介素-18受体α链抗体
Alias	interleukin-18 receptor alpha chain; Interleukin-18 receptor 1; IL-18R-1; IL-18R1; IL1 receptor-related protein; interleukin 1 receptor-like protein; IL-1Rrp; IL1R-rp; CD218 antigen-like family member A; CD218a; CDw218; CDw218a; CDw218a antigen; IL18RA; Il18ralpha; IL1RRP; interleukin 18 receptor 1.
literatures	Specific References  (3)     |     SL2615R has been referenced in 3 publications. [IF=5.383] Ting Xiang. et al. Spinal CCK1 receptors contribute to somatic pain hypersensitivity induced by malocclusion via a reciprocal neuron-glial signaling cascade. J PAIN. 2022 Jun;:  IHC ;  Rat.   PubMed:35691467 [IF=2.08] Zhang, Jihong, et al. "Interleukin 18 augments growth ability via NF-κB and p38/ATF2 pathways by targeting cylin B1, cyclin B2, cylin A2, and Bcl-2 in BRL-3A rat liver cells." Gene (2015).  WB ;  Rat.   PubMed:25752290 [IF=1.585] Jiang et al. Detection of Atherosclerotic Plaques in the Rabbit Aorta Using Ultrasound Microbubbles Conjugated to Interleukin-18 Antibodies. (2017) Med.Sci.Moni. 23:5446-5454  Other ;  Rabbit.   PubMed:29142190
Research Area	Tumour  Cell biology  immunology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	60kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-18R alpha: 21-120/541 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] Function: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B. Subunit: Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines. Similarity: Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain. SWISS: Q13478 Gene ID: 8809 Database links: Entrez Gene: 8809 Human Omim: 604494 Human SwissProt: Q13478 Human Unigene: 469521 Human
Product Picture	Sample: Lane 1: Mouse Blood cell lysates Lane 2: Mouse Lung tissue lysates Primary: Anti-IL-18R alpha (SL2615R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60 kDa Observed band size: 70 kDa Blank control(blue): Raji (fixed with 2% paraformaldehyde (10 min) , then permeabilized with 90% ice-cold methanol for 30 min on ice). Primary Antibody: Rabbit Anti-IL-18R alpha antibody(SL2615R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange),used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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