Product Name	IL17C
Chinese Name	白介素-17C抗体
Alias	Interleukin-17C; IL17C; CX2; IL-17C; IL 17C; IL-21; IL 21; MGC126884; MGC138401; Cytokine CX2; IL17C_HUMAN.
literatures	Specific References  (4)     |     SL2611R has been referenced in 4 publications. [IF=6.676] Takuya Takeichi. et al. Ceramide analysis in combination with genetic testing may provide a precise diagnosis for self-healing collodion babies. J LIPID RES. 2022 Nov;:100308  IHC ;  Human.   PubMed:36332686 [IF=5.9] Huang et al. IL-17C is required for lethal inflammation during systemic fungal infection. (2016) Cell.Mol.Immunol. 13:474-83  IHC ;  Mouse.   PubMed:26166766 [IF=4.99] Huang, Jinling, et al. "IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis." The Journal of Immunology (2016): 1600977.  IHC-P ;  Mouse.   PubMed:27956525 [IF=2.952] Xiaoyan Pu. et al. Oxidative stress and expression of inflammatory factors in lung tissue of acute mountain sickness rats. Mol Med Rep. 2022 Feb;25(2):1-7  WB ;  Rat.   PubMed:34913080
Research Area	immunology  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	20kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-17C: 101-197/197
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq]. Function: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. Subcellular Location: Secreted. Similarity: Belongs to the IL-17 family. SWISS: Q9P0M4 Gene ID: 27189 Database links: Entrez Gene: 27189 Human Omim: 604628 Human SwissProt: Q9P0M4 Human Unigene: 278911 Human
Product Picture	Sample: Lane1: Lung(Rat) Lysate at 30 ug Lane2: Pancreas(Rat) Lysate at 30 ug Primary: Anti-IL-17C (SL2611R) at 1:200 dilution; Secondary: HRP conjugated Goat Anti-Rabbit IgG(SL0295G-HRP) at 1: 3000 dilution; Predicted band size : 20kD Observed band size : 22kD Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL17C) Polyclonal Antibody, Unconjugated (SL2611R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: Human colon cancer tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL17C Polyclonal Antibody, Unconjugated(SL2611R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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